Expression of human fos proto-oncogene (c-fos) was analyzed in primary cells from 50 untreated acute lymphocytic (ALL) and myeloblastic (AML) leukemias. c-fos RNA, analyzed by blot hybridization, was detected virtually only in myelomonocytic (M4) and monocytic (M5) AML. Both M4 and M5 samples show a strong positive correlation between the amount of c-fos transcripts and the percentage of leukemic cells expressing surface antigens specific for mature monocytes and macrophages. Normal mature monocytes exhibit a detectable level of c-fos RNA, which is virtually unaltered on activation to macrophage differentiation, but is always below that observed in M4 through M5 monocyticlike cells. These data provide evidence that c-fos expression is linked to terminal monocyte and macrophage differentiation in normal and leukemic hemopoiesis.
Selective expression of fos proto-oncogene in human acute myelomonocytic and monocytic leukemias: A molecular marker of terminal differentiation / Mavilio, F.; Testa, U.; Sposi, N. M.; Petrini, M.; Pelosi, E.; Bordignon, C.; Amadori, S.; Mandelli, F.; Peschle, C.. - In: BLOOD. - ISSN 0006-4971. - 69:1(1987), pp. 160-164. [10.1182/blood.v69.1.160.bloodjournal691160]
Selective expression of fos proto-oncogene in human acute myelomonocytic and monocytic leukemias: A molecular marker of terminal differentiation
Mavilio F.;
1987
Abstract
Expression of human fos proto-oncogene (c-fos) was analyzed in primary cells from 50 untreated acute lymphocytic (ALL) and myeloblastic (AML) leukemias. c-fos RNA, analyzed by blot hybridization, was detected virtually only in myelomonocytic (M4) and monocytic (M5) AML. Both M4 and M5 samples show a strong positive correlation between the amount of c-fos transcripts and the percentage of leukemic cells expressing surface antigens specific for mature monocytes and macrophages. Normal mature monocytes exhibit a detectable level of c-fos RNA, which is virtually unaltered on activation to macrophage differentiation, but is always below that observed in M4 through M5 monocyticlike cells. These data provide evidence that c-fos expression is linked to terminal monocyte and macrophage differentiation in normal and leukemic hemopoiesis.
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