We investigated the replicative profile of hepatitis B (HBV) and hepatitis C (HCV) viruses and the mutational pattern of the HBV precore/core (pre-C/C) domain in hepatocellular carcinoma (HCC). Thirty-eight consecutive patients with HCC were included in the study - 18 of them with HBV/HCV co-infection and 20 with HBV single infection. Twenty-three additional patients with co-infection, without HCC were recruited as the control group. Replication activity was evaluated by detecting and quantitating both HBV and HCV genomes. The HBV pre-C/C region, encompassing the pregenome encapsidation signal involved in viral replication, was analysed by direct sequencing. HBV viraemia levels were significantly lower (P = 0.04) in patients with co-infection in comparison with single-infected HCC, whereas two different HBV viraemia profiles were detected in co-infection with or without circulating HCV. HBV genotype D was prevalent in the three groups and HCV genotype 1b was found to be the infecting strain in all patients. Lower variability in the pre-C/C region was found in co-infection in comparison with HBV single infection (P = 0.0004). A synonymous T1936C mutation was found in all co-infected HCC cases not related to the presence or absence of circulating HCV, and a hypermutated pre-C strain, characterized by the same mutational pattern, was identified in three HCC cases. The mutational pattern of the pre-C/C region was closely related to HBV replication efficiency, and specific HBV mutations selectively associated with HCV co-infection could be linked with accelerated HBV/HCV-related disease progression. © 2006 The Authors.
Virological analysis, genotypes and mutational patterns of the HBV pre-core/core gene in HBV/HCV-related hepatocellular carcinoma / De Mitri, Maria Stella; Cassini, Romina; Morsica, G; Bagaglio, S; Andreone, Pietro; Loggi, Elisabetta; Muratori, Paolo; Bernardi, Mauro. - In: JOURNAL OF VIRAL HEPATITIS. - ISSN 1352-0504. - 13:9(2006), pp. 574-581. [10.1111/j.1365-2893.2006.00726.x]
Data di pubblicazione: | 2006 | |
Titolo: | Virological analysis, genotypes and mutational patterns of the HBV pre-core/core gene in HBV/HCV-related hepatocellular carcinoma | |
Autore/i: | De Mitri, Maria Stella; Cassini, Romina; Morsica, G; Bagaglio, S; Andreone, Pietro; Loggi, Elisabetta; Muratori, Paolo; Bernardi, Mauro | |
Autore/i UNIMORE: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1365-2893.2006.00726.x | |
Rivista: | ||
Volume: | 13 | |
Fascicolo: | 9 | |
Pagina iniziale: | 574 | |
Pagina finale: | 581 | |
Codice identificativo ISI: | WOS:000239779000002 | |
Codice identificativo Scopus: | 2-s2.0-33747298123 | |
Citazione: | Virological analysis, genotypes and mutational patterns of the HBV pre-core/core gene in HBV/HCV-related hepatocellular carcinoma / De Mitri, Maria Stella; Cassini, Romina; Morsica, G; Bagaglio, S; Andreone, Pietro; Loggi, Elisabetta; Muratori, Paolo; Bernardi, Mauro. - In: JOURNAL OF VIRAL HEPATITIS. - ISSN 1352-0504. - 13:9(2006), pp. 574-581. [10.1111/j.1365-2893.2006.00726.x] | |
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