OBJECTIVES: Although the etiology of liver disease affects the features of hepatocellular carcinoma (HCC) diagnosed during surveillance, it is not known whether it influences patients' survival. We analyzed the impact of etiology on the characteristics and outcome of HCC detected during surveillance. METHODS: In this cohort study, 742 patients with HCC detected during semiannual or annual surveillance were selected from the ITA.LI.CA database, including 1,834 consecutive patients observed in three primary and seven tertiary care settings for HCC. Patients were grouped according to etiology: hepatitis B virus (HBV, 87), hepatitis C virus (HCV, 461), alcohol (59), and multietiology (135). RESULTS: In all etiologic groups, most HCCs were unifocal (51-68%) and most of them were
Impact of etiology of cirrhosis on the survival of patients diagnosed with hepatocellular carcinoma during surveillance / Trevisani, Franco; Magini, Giulia; Santi, Valentina; Maria Morselli-Labate, Antonio; Chiara Cantarini, Maria; Anna Di Nolfo, Maria; Del Poggio, Paolo; Benvegnù, Luisa; Rapaccini, Gianludovico; Farinati, Fabio; Zoli, Marco; Borzio, Franco; Giovanni Giannini, Edoardo; Caturelli, Eugenio; Bernardi, Mauro; CA) Group, for the Italian Liver Cancer (ITA. LI.; Andreone, Pietro; Biselli, Maurizio; Caraceni, Paolo; Chiara Cantarini, Maria; Cursaro, Carmela; Domenicali, Marco; Gramenzi, Annagiulia; Silvia, Li Bassi; Magalotti, Donatella; Mirici Cappa, Federica; Zambruni, Andrea; Luca Grazi, Gian; Nardo, Bruno; Ravaioli, Matteo; Rossi, Cristina; Golfieri, Rita. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - 102:5(2007), pp. 1022-1031. [10.1111/j.1572-0241.2007.01100.x]
Impact of etiology of cirrhosis on the survival of patients diagnosed with hepatocellular carcinoma during surveillance
Mauro Bernardi;Pietro Andreone;Carmela Cursaro;
2007
Abstract
OBJECTIVES: Although the etiology of liver disease affects the features of hepatocellular carcinoma (HCC) diagnosed during surveillance, it is not known whether it influences patients' survival. We analyzed the impact of etiology on the characteristics and outcome of HCC detected during surveillance. METHODS: In this cohort study, 742 patients with HCC detected during semiannual or annual surveillance were selected from the ITA.LI.CA database, including 1,834 consecutive patients observed in three primary and seven tertiary care settings for HCC. Patients were grouped according to etiology: hepatitis B virus (HBV, 87), hepatitis C virus (HCV, 461), alcohol (59), and multietiology (135). RESULTS: In all etiologic groups, most HCCs were unifocal (51-68%) and most of them were
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