Tenofovir disoproxil fumarate (TDF) is a nucleotide reverse transcriptase inhibitor indicated for treatment of patients with chronic hepatitis B virus (CHB) and human immunodeficiency virus (HIV) infections. Despite the good safety profile of the drug, Fanconi syndrome is a possible adverse reaction of TDF treatment, especially in HIV-infected patients. Only a few cases have been reported in patients with CHB-monoinfections. This report presents a case of a 58-year-old man with mild HBeAg-negative CHB who was exposed to TDF and developed drug-induced Fanconi syndrome. Renal dysfunction reverted after TDF discontinuation and a switch to entecavir, and viral replication remained suppressed. A literature review yielded six additional cases of TDF-induced Fanconi syndrome, all with risk factors for renal dysfunction despite the patients having normal glomerular filtration rates. We discuss the overall risk for Fanconi syndrome in CHB-monoinfected patients exposed to TDF and the importance of careful monitoring of glomerular and tubular functions even when pre-existing kidney disease is not present.

Tenofovir-induced Fanconi syndrome in a patient with chronic hepatitis B monoinfection / Conti, Fabio; Vitale, Giovanni; Cursaro, C; Bernardi, Mauro; Andreone, Pietro. - In: ANNALS OF HEPATOLOGY. - ISSN 1665-2681. - 15:(2016), pp. 273-276. [10.5604/16652681.1193725]

Tenofovir-induced Fanconi syndrome in a patient with chronic hepatitis B monoinfection

BERNARDI, MAURO;ANDREONE, PIETRO
2016

Abstract

Tenofovir disoproxil fumarate (TDF) is a nucleotide reverse transcriptase inhibitor indicated for treatment of patients with chronic hepatitis B virus (CHB) and human immunodeficiency virus (HIV) infections. Despite the good safety profile of the drug, Fanconi syndrome is a possible adverse reaction of TDF treatment, especially in HIV-infected patients. Only a few cases have been reported in patients with CHB-monoinfections. This report presents a case of a 58-year-old man with mild HBeAg-negative CHB who was exposed to TDF and developed drug-induced Fanconi syndrome. Renal dysfunction reverted after TDF discontinuation and a switch to entecavir, and viral replication remained suppressed. A literature review yielded six additional cases of TDF-induced Fanconi syndrome, all with risk factors for renal dysfunction despite the patients having normal glomerular filtration rates. We discuss the overall risk for Fanconi syndrome in CHB-monoinfected patients exposed to TDF and the importance of careful monitoring of glomerular and tubular functions even when pre-existing kidney disease is not present.
2016
15
273
276
Tenofovir-induced Fanconi syndrome in a patient with chronic hepatitis B monoinfection / Conti, Fabio; Vitale, Giovanni; Cursaro, C; Bernardi, Mauro; Andreone, Pietro. - In: ANNALS OF HEPATOLOGY. - ISSN 1665-2681. - 15:(2016), pp. 273-276. [10.5604/16652681.1193725]
Conti, Fabio; Vitale, Giovanni; Cursaro, C; Bernardi, Mauro; Andreone, Pietro
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1237154
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