A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10−11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10−10, OR = 1.63) and 17q12-21 (P = 1.7 × 10−10, OR = 1.38).
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis / Liu, X., Invernizzi, P., Lu, Y., Kosoy, R., Lu, Y., Bianchi, I., Podda, M., Xu, C., Xie, G., Macciardi, F., Selmi, C., Lupoli, S., Shigeta, R., Ransom, M., Lleo, A., Lee, A.t., Mason, A.l., Myers, R.p., Peltekian, K.m., Ghent, C.n., et al.. - In: NATURE GENETICS. - ISSN 1061-4036. - 42:8(2010), pp. 658-660. [10.1038/ng.627]
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
MURATORI, LUIGI;ANDREONE, PIETRO;MARGOTTI, MARZIA;
2010
Abstract
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10−11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10−10, OR = 1.63) and 17q12-21 (P = 1.7 × 10−10, OR = 1.38).
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