A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10−11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10−10, OR = 1.63) and 17q12-21 (P = 1.7 × 10−10, OR = 1.38).
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis / Liu, X; Invernizzi, P; Lu, Y; Kosoy, R; Lu, Y; Bianchi, I; Podda, M; Xu, C; Xie, G; Macciardi, F; Selmi, C; Lupoli, S; Shigeta, R; Ransom, M; Lleo, A; Lee, At; Mason, Al; Myers, Rp; Peltekian, Km; Ghent, Cn; Bernuzzi, F; Zuin, M; Rosina, F; Borghesio, E; Floreani, A; Lazzari, R; Niro, G; Andriulli, A; Muratori, Luigi; Muratori, Paolo; Almasio, Pl; Andreone, Pietro; Margotti, Marzia; Brunetto, M; Coco, B; Alvaro, D; Bragazzi, Mc; Marra, F; Pisano, A; Rigamonti, C; Colombo, M; Marzioni, M; Benedetti, A; Fabris, L; Strazzabosco, M; Portincasa, P; Palmieri, Vo; Tiribelli, C; Croce, L; Bruno, S; Rossi, S; Vinci, M; Prisco, C; Mattalia, A; Toniutto, P; Picciotto, A; Galli, A; Ferrari, C; Colombo, S; Casella, G; Morini, L; Caporaso, N; Colli, A; Spinzi, G; Montanari, R; Gregersen, Pk; Heathcote, Ej; Hirschfield, Gm; Siminovitch, Ka; Amos, Ci; Gershwin, Me; Seldin, M. F.. - In: NATURE GENETICS. - ISSN 1061-4036. - 42:8(2010), pp. 658-660. [10.1038/ng.627]
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
MURATORI, LUIGI;ANDREONE, PIETRO;MARGOTTI, MARZIA;
2010
Abstract
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10−11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10−10, OR = 1.63) and 17q12-21 (P = 1.7 × 10−10, OR = 1.38).
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