We present the case of a 69-year-old woman who attended the Endocrinology Unit of Modena for a suspicious lymph node in the left cervical compartment discovered during the follow-up of a recurrent gynecological malignancy. At neck ultrasonography, a thyroid goiter was detected, and the further cytological examination was inconclusive for thyroid nodule and compatible with a localization of an adenocarcinoma with papillary architecture for the lymph node. The histological examination after a left neck dissection confirmed the presence of an intracapsular metastasis of a papillary carcinoma immunohistochemically focally positive for thyroid transcription factor 1 and paired box 8 and negative for thyroglobulin. Subsequently, in the suspicion of a thyroid primitiveness, a total thyroidectomy was performed, revealing an intraparenchymal follicular variant of papillary thyroid carcinoma of 2 mm in the right lobe. During the follow-up, the appearance of a suspected cervical metastatic lesion led to another neck dissection, histologically compatible with a papillary carcinoma localization, immunohistochemically focally positive for thyroid transcription factor 1 and paired box 8, and negative for thyroglobulin. The histological revision of surgical specimens suggests the cervical recurrence of the prior gynecological cancer, rather than a thyroid carcinoma metastasis. The case described shows how carefully the cytological, histological and immunoistochemical results must be evaluated in oncological management, considering the whole patient’s history.

Gynecological malignancy mimicking a thyroid lymph node metastasis / Pederzoli, S.; Spaggiari, G.; Bernardelli, G.; Mattioli, F.; Baldessari, C.; Maiorana, A.; Rochira, V.; Santi, D.. - In: ENDOCRINOLOGY, DIABETES & METABOLISM CASE REPORTS. - ISSN 2052-0573. - 20-005S:(2021), pp. 1-8. [10.1530/EDM-20-0055]

Gynecological malignancy mimicking a thyroid lymph node metastasis.

S. Pederzoli;G. Bernardelli;F. Mattioli;A. Maiorana;V. Rochira;D. Santi
2021

Abstract

We present the case of a 69-year-old woman who attended the Endocrinology Unit of Modena for a suspicious lymph node in the left cervical compartment discovered during the follow-up of a recurrent gynecological malignancy. At neck ultrasonography, a thyroid goiter was detected, and the further cytological examination was inconclusive for thyroid nodule and compatible with a localization of an adenocarcinoma with papillary architecture for the lymph node. The histological examination after a left neck dissection confirmed the presence of an intracapsular metastasis of a papillary carcinoma immunohistochemically focally positive for thyroid transcription factor 1 and paired box 8 and negative for thyroglobulin. Subsequently, in the suspicion of a thyroid primitiveness, a total thyroidectomy was performed, revealing an intraparenchymal follicular variant of papillary thyroid carcinoma of 2 mm in the right lobe. During the follow-up, the appearance of a suspected cervical metastatic lesion led to another neck dissection, histologically compatible with a papillary carcinoma localization, immunohistochemically focally positive for thyroid transcription factor 1 and paired box 8, and negative for thyroglobulin. The histological revision of surgical specimens suggests the cervical recurrence of the prior gynecological cancer, rather than a thyroid carcinoma metastasis. The case described shows how carefully the cytological, histological and immunoistochemical results must be evaluated in oncological management, considering the whole patient’s history.
1-gen-2021
20-005S
1
8
Gynecological malignancy mimicking a thyroid lymph node metastasis / Pederzoli, S.; Spaggiari, G.; Bernardelli, G.; Mattioli, F.; Baldessari, C.; Maiorana, A.; Rochira, V.; Santi, D.. - In: ENDOCRINOLOGY, DIABETES & METABOLISM CASE REPORTS. - ISSN 2052-0573. - 20-005S:(2021), pp. 1-8. [10.1530/EDM-20-0055]
Pederzoli, S.; Spaggiari, G.; Bernardelli, G.; Mattioli, F.; Baldessari, C.; Maiorana, A.; Rochira, V.; Santi, D.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1235311
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