Background: Treatment with integrase strand transfer inhibitors (INSTIs) has been associated with excess weight gain, however the long-term effect of INSTI-based regimens on adipose tissue (AT) compartments remains unknown. Objectives: To evaluate the effect of switching to an INSTI on visceral (VAT) and subcutaneous (SAT) AT in virologically-suppressed adults with HIV. Methods: We performed a retrospective observational cohort study of ART experienced adults referred to the metabolic Clinic of the University of Modena and Reggio Emilia who had ≥2 assessments of body composition by abdominal computed tomography. An interrupted time series model with mixed-effect model incorporated was used to calculate VAT and SAT change rate, adjusting for smoking status, use of alcohol, and physical activity. Results: A total of 698 patients were included: 156 who switched to an INSTI-based regimen and 542 who did not. After switch to INSTI, mean SAT area increased approximately 3-fold (before 0.27 vs after 0.73 cm2/month; p = 0.011), and VAT area 7-fold (0.18 vs 1.30 cm2/month; p < 0.001). Conclusions: Among PLWH on ART, both SAT and VAT gain accelerated after switching to an INSTI-based regimen. The associations between INSTIs and central adiposity require further investigation.

Changes in central adipose tissue after switching to integrase inhibitors / Debroy, Paula; Feng, Han; Miao, Hongyu; Milic, Jovana; Ligabue, Guido; Draisci, Stefano; Besutti, Giulia; Carli, Federica; Menozzi, Marianna; Mussini, Cristina; Guaraldi, Giovanni; Lake, Jordan E. - In: HIV RESEARCH & CLINICAL PRACTICE. - ISSN 2578-7489. - 21:6(2021), pp. 168-173. [10.1080/25787489.2020.1848131]

Changes in central adipose tissue after switching to integrase inhibitors

Milic, Jovana;Ligabue, Guido;Draisci, Stefano;Besutti, Giulia;Carli, Federica;Menozzi, Marianna;Mussini, Cristina;Guaraldi, Giovanni;
2021-01-01

Abstract

Background: Treatment with integrase strand transfer inhibitors (INSTIs) has been associated with excess weight gain, however the long-term effect of INSTI-based regimens on adipose tissue (AT) compartments remains unknown. Objectives: To evaluate the effect of switching to an INSTI on visceral (VAT) and subcutaneous (SAT) AT in virologically-suppressed adults with HIV. Methods: We performed a retrospective observational cohort study of ART experienced adults referred to the metabolic Clinic of the University of Modena and Reggio Emilia who had ≥2 assessments of body composition by abdominal computed tomography. An interrupted time series model with mixed-effect model incorporated was used to calculate VAT and SAT change rate, adjusting for smoking status, use of alcohol, and physical activity. Results: A total of 698 patients were included: 156 who switched to an INSTI-based regimen and 542 who did not. After switch to INSTI, mean SAT area increased approximately 3-fold (before 0.27 vs after 0.73 cm2/month; p = 0.011), and VAT area 7-fold (0.18 vs 1.30 cm2/month; p < 0.001). Conclusions: Among PLWH on ART, both SAT and VAT gain accelerated after switching to an INSTI-based regimen. The associations between INSTIs and central adiposity require further investigation.
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Changes in central adipose tissue after switching to integrase inhibitors / Debroy, Paula; Feng, Han; Miao, Hongyu; Milic, Jovana; Ligabue, Guido; Draisci, Stefano; Besutti, Giulia; Carli, Federica; Menozzi, Marianna; Mussini, Cristina; Guaraldi, Giovanni; Lake, Jordan E. - In: HIV RESEARCH & CLINICAL PRACTICE. - ISSN 2578-7489. - 21:6(2021), pp. 168-173. [10.1080/25787489.2020.1848131]
Debroy, Paula; Feng, Han; Miao, Hongyu; Milic, Jovana; Ligabue, Guido; Draisci, Stefano; Besutti, Giulia; Carli, Federica; Menozzi, Marianna; Mussini, Cristina; Guaraldi, Giovanni; Lake, Jordan E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1227495
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