Clinical and electrocardiographic characteristics at admission of COVID-19/SARS-CoV2 pneumonia infection

Denegri, A.; Pezzuto, G.; D'Arienzo, M.; Morelli, M.; Savorani, F.; Cappello, C. G.; Luciani, A.; Boriani, G.

doi:10.1007/s11739-020-02578-8

Background: The aim of the present study was to compare clinical and electrocardiographic characteristics of patients with COVID-19 pneumonia in Modena, Emilia Romagna, Italy. Methods: Patients admitted to the emergency department for suspected COVID-19 pneumonia from March the 16th to April the 15th were enrolled in the study. COVID-19 pneumonia was confirmed by positive nasopharyngeal swab. Primary endpoint was 30-day mortality. Results: 201 patients were diagnosed with COVID-19 pneumonia. Compared to survivors, patients who died were older (79.7 ± 10.8 vs 65.6 ± 14.1, p < 0.001), with a more complex cardiovascular history, including coronary artery disease (CAD, 33.3% vs 13.3%, p = 0.004), atrial fibrillation (23.8 vs 8.8, p = 0.011) and chronic kidney disease (CKD 35.7% vs 7.0%, p < 0.001). 30-day mortality was 20,9% in these patients; atrial fibrillation (OR 12.74, 95% CI 3.65–44.48, p < 0.001), ST-segment depression (OR 5.30, 95% CI 1.50–18.81, p = 0.010) and QTc-interval prolongation (OR 3.17, 95% CI 1.24–8.10, p = 0.016) at ECG admission were associated to an increased mortality risk. On the contrary, sinus rhythm (OR 0.08, 95% CI 0.02–0.27, p < 0.001) and low-molecular weight heparin (LMWH) administration (OR 0.08, 95% CI 0.02–0.29, p < 0.001) were related to reduced mortality. At multivariate analysis, after adjustment for age, sex, diabetes, CAD, and MCA admission, sinus rhythm (HR 2.7, CI 95% 1.1–7.0, p = 0.038) and LMWH (HR 8.5, 95% CI 2.0–36.6, p = 0.004) were confirmed to be independent predictors of increased survival. Conclusion: Sinus rhythm at ECG admission in COVID-19 pneumonia patients was associated with greater survival as well as LMWH administration, which conferred an overall better outcome.

Clinical and electrocardiographic characteristics at admission of COVID-19/SARS-CoV2 pneumonia infection / Denegri, A.; Pezzuto, G.; D'Arienzo, M.; Morelli, M.; Savorani, F.; Cappello, C. G.; Luciani, A.; Boriani, G.. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - (2021), pp. N/A-N/A.

Data di pubblicazione:	2021
Titolo:	Clinical and electrocardiographic characteristics at admission of COVID-19/SARS-CoV2 pneumonia infection
Autore/i:	Denegri, A.; Pezzuto, G.; D'Arienzo, M.; Morelli, M.; Savorani, F.; Cappello, C. G.; Luciani, A.; Boriani, G.
Autore/i UNIMORE:	Denegri A. PEZZUTO, Giuseppe Stefano D'Arienzo M. Morelli M. SAVORANI, FRANCESCO Cappello C. G. Luciani A. BORIANI, Giuseppe mostra contributor esterni nascondi contributor esterni
Digital Object Identifier (DOI):	http://dx.doi.org/10.1007/s11739-020-02578-8
Rivista:	INTERNAL AND EMERGENCY MEDICINE
Pagina iniziale:	N/A
Pagina finale:	N/A
Codice identificativo Scopus:	2-s2.0-85098994107
Codice identificativo Pubmed:	33398608
Citazione:	Clinical and electrocardiographic characteristics at admission of COVID-19/SARS-CoV2 pneumonia infection / Denegri, A.; Pezzuto, G.; D'Arienzo, M.; Morelli, M.; Savorani, F.; Cappello, C. G.; Luciani, A.; Boriani, G.. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - (2021), pp. N/A-N/A.
Tipologia	Articolo su rivista

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