Long-term synaptic plasticity is thought to provide the substrate for adaptive computation in brain circuits but very little is known about its spatiotemporal organization. Here, we combined multi-spot two-photon laser microscopy in rat cerebellar slices with realistic modeling to map the distribution of plasticity in multi-neuronal units of the cerebellar granular layer. The units, composed by ~300 neurons activated by ~50 mossy fiber glomeruli, showed long-term potentiation concentrated in the core and long-term depression in the periphery. This plasticity was effectively accounted for by an NMDA receptor and calcium-dependent induction rule and was regulated by the inhibitory Golgi cell loops. Long-term synaptic plasticity created effective spatial filters tuning the time-delay and gain of spike retransmission at the cerebellum input stage and provided a plausible basis for the spatiotemporal recoding of input spike patterns anticipated by the motor learning theory.

Cellular-resolution mapping uncovers spatial adaptive filtering at the rat cerebellum input stage / Casali, S.; Tognolina, M.; Gandolfi, D.; Mapelli, J.; D'Angelo, E.. - In: COMMUNICATIONS BIOLOGY. - ISSN 2399-3642. - 3:1(2020), pp. 635-635. [10.1038/s42003-020-01360-y]

Cellular-resolution mapping uncovers spatial adaptive filtering at the rat cerebellum input stage

Gandolfi D.;Mapelli J.;
2020

Abstract

Long-term synaptic plasticity is thought to provide the substrate for adaptive computation in brain circuits but very little is known about its spatiotemporal organization. Here, we combined multi-spot two-photon laser microscopy in rat cerebellar slices with realistic modeling to map the distribution of plasticity in multi-neuronal units of the cerebellar granular layer. The units, composed by ~300 neurons activated by ~50 mossy fiber glomeruli, showed long-term potentiation concentrated in the core and long-term depression in the periphery. This plasticity was effectively accounted for by an NMDA receptor and calcium-dependent induction rule and was regulated by the inhibitory Golgi cell loops. Long-term synaptic plasticity created effective spatial filters tuning the time-delay and gain of spike retransmission at the cerebellum input stage and provided a plausible basis for the spatiotemporal recoding of input spike patterns anticipated by the motor learning theory.
2020
3
1
635
635
Cellular-resolution mapping uncovers spatial adaptive filtering at the rat cerebellum input stage / Casali, S.; Tognolina, M.; Gandolfi, D.; Mapelli, J.; D'Angelo, E.. - In: COMMUNICATIONS BIOLOGY. - ISSN 2399-3642. - 3:1(2020), pp. 635-635. [10.1038/s42003-020-01360-y]
Casali, S.; Tognolina, M.; Gandolfi, D.; Mapelli, J.; D'Angelo, E.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1227025
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