Background: No specific features of nevus-associated melanoma (NAM) are currently defined. Objective: To identify clinical/dermoscopic features of NAM. Methods: Retrospective evaluation of histopathologically diagnosed NAM. Results: Eighty of 165 NAMs had a clinically recognizable nevus component, often raised or nodular, most frequently characterized by different morphologic clones and/or colors. In 111 of 165 NAMs, dermoscopy showed a nevus component, prevalently characterized by regular dots/clods and structureless brown areas. Clinically, the melanoma component was eccentric/peripheral in 45 of 80 cases and central in 35 of 80; dermoscopically, the figures were 59 of 111 and 52 of 111, respectively. Melanomas associated with congenital nevi (C-NAMs) occur at a younger age and have a thicker Breslow depth than melanomas associated with acquired nevi (NC-NAMs). Dermoscopically, regular dots/globules characterize C-NAMs, and hypopigmented structureless areas characterize NC-NAMs. Limitations: Retrospective analysis. Conclusion: C-NAMs are more often central to a congenital nevus, with a clod/globular or structureless brown pattern, typical of young patients. NC-NAMs are frequently hypopigmented nodules/plaques, eccentric/peripheral, with hypopigmented structureless areas, typical of older patients.

Clinical and dermoscopic characteristics of congenital and noncongenital nevus-associated melanomas / Zalaudek, I.; Conforti, C.; Guarneri, F.; Vezzoni, R.; Deinlein, T.; Hofmann-Wellenhof, R.; Longo, C.; Moscarella, E.; Kittler, H.; Argenziano, G.; Giuffrida, R.. - In: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. - ISSN 0190-9622. - 83:4(2020), pp. 1080-1087.

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