Epigenetic and genetic alterations are two mechanisms participating in leukemia, which can inactivate genes involved in leukemia pathogenesis or progression. The purpose of this review was to introduce various inactivated genes and evaluate their possible role in leukemia pathogenesis and prognosis. By searching the mesh words "Gene, Silencing AND Leukemia" in PubMed website, relevant English articles dealt with human subjects as of 2000 were included in this study. Gene inactivation in leukemia is largely mediated by promoter's hypermethylation of gene involving in cellular functions such as cell cycle, apoptosis, and gene transcription. Inactivated genes, such as ASPP1, TP53, IKZF1 and P15, may correlate with poor prognosis in acute lymphoid leukemia (ALL), chronic lymphoid leukemia (CLL), chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML), respectively. Gene inactivation may play a considerable role in leukemia pathogenesis and prognosis, which can be considered as complementary diagnostic tests to differentiate different leukemia types, determine leukemia prognosis, and also detect response to therapy. In general, this review showed some genes inactivated only in leukemia (with differences between B-ALL, T-ALL, CLL, AML and CML). These differences could be of interest as an additional tool to better categorize leukemia types. Furthermore; based on inactivated genes, a diverse classification of Leukemias could represent a powerful method to address a targeted therapy of the patients, in order to minimize side effects of conventional therapies and to enhance new drug strategies.
Significance of Inactivated Genes in Leukemia: Pathogenesis and Prognosis / Heidari, N.; Abroun, S.; Bertacchini, J.; Vosoughi, T.; Rahim, F.; Saki, N.. - In: THE OPEN STEM CELL JOURNAL. - ISSN 1876-8938. - 19:Suppl 1(2017), pp. 9-26.
|Data di pubblicazione:||2017|
|Titolo:||Significance of Inactivated Genes in Leukemia: Pathogenesis and Prognosis|
|Autore/i:||Heidari, N.; Abroun, S.; Bertacchini, J.; Vosoughi, T.; Rahim, F.; Saki, N.|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.22074/cellj.2017.4908|
|Codice identificativo ISI:||WOS:000402452400002|
|Codice identificativo Scopus:||2-s2.0-85020018293|
|Codice identificativo Pubmed:||28580304|
|Citazione:||Significance of Inactivated Genes in Leukemia: Pathogenesis and Prognosis / Heidari, N.; Abroun, S.; Bertacchini, J.; Vosoughi, T.; Rahim, F.; Saki, N.. - In: THE OPEN STEM CELL JOURNAL. - ISSN 1876-8938. - 19:Suppl 1(2017), pp. 9-26.|
|Tipologia||Articolo su rivista|
File in questo prodotto:
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris