Mutations and Drugs Portal (MDP): A database linking drug response data and genomic information

The integration of large-scale genomic and pharmacological data from cancer cell lines promises to be effective in the discovery of new genetic markers of drug sensitivity and of clinically relevant anticancer compounds. The Mutations and Drugs Portal (MDP, http://mdp.unimore.it) is a web accessible database that combines the cell-based NCI60 pharmacological screening with genomic data extracted from the Cancer Cell Line Encyclopedia and the NCI60 DTP projects. MDP currently contains drug sensitivity data for more than 50,800 compounds, describing response to drugs across 115 cancer cell lines. To identify genomic features associated to drug response, cell line drug sensitivity data are integrated with large genomic datasets, including information on somatic mutations and transcriptional data. MDP can be queried for drugs active in cancer cell lines carrying mutations or transcriptional alterations in specific cancer genes and signaling pathways or for genetic and transcriptional profiles associated to sensitivity or resistance to a given compound. Results are presented through graphical representations with links to related data and are fully downloadable. MDP provides a user-friendly web resource to perform in-silico high-throughput screenings of thousand of compounds and facilitate the discovery of associations between genomic portraits and drug responses.