Activation of phosphatidylinositol (PI) 3-kinase, protein kinase A (PKA) and protein kinase C (PKC) is associated with the survival effect elicited by PDGF-AB and TGF-β1 against the apoptotic inducer 2-deoxy-D-ribose (dRib) in the fat body cell line, IPLB-LdFB, from the insect Lymantria dispar. dRib induces apoptosis and provokes mitochondrial membrane depolarization (MMD). The antioxidant N-acetyl-L-cysteine annuls only the first effect. These findings suggest that apoptosis and MMD are provoked by two different mechanisms, and that dRib induces apoptosis by oxidative stress. © 2001 Academic Press.
Involvement of PI 3-kinase, PKA and PKC in PDGF- and TGF-β-mediated prevention of 2-deoxy-D-ribose-induced apoptosis in the insect cell line, IPLB-LdFB / Ottaviani, E.; Barbieri, D.; Malagoli, D.; Kletsas, D.. - In: CELL BIOLOGY INTERNATIONAL. - ISSN 1065-6995. - 25:2(2001), pp. 171-177. [10.1006/cbir.2000.0582]