Conducting polymer electrodes based on poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) are used to record extracellular signals from autonomous cardiac contractile cells and glioma cell cultures. The performance of these conducting polymer electrodes is compared with Au electrodes. A small-signal impedance analysis shows that in the presence of an electrolyte, both Au and polymer electrodes establish high capacitive double-layers. However, the polymer/electrolyte interfacial resistance is 3 orders of magnitude lower than the resistance of the metal/electrolyte interface. The polymer low interfacial resistance minimizes the intrinsic thermal noise and increases the system sensitivity. However, when measurements are carried out in current mode a low interfacial resistance partially acts as a short circuit of the interfacial capacitance, this affects the signal shape.

Performance assessment of polymer based electrodes for in vitro electrophysiological sensing: The role of the electrode impedance / Medeiros, M. C. R.; Mestre, A. L. G.; Inacio, P. M. C.; Santos, J. M. L.; Araujo, I. M.; Braganca, J.; Biscarini, F.; Gomes, H. L.. - 9944:(2016), p. 994404. (Intervento presentato al convegno Organic Sensors and Bioelectronics IX tenutosi a usa nel 2016) [10.1117/12.2237659].

Performance assessment of polymer based electrodes for in vitro electrophysiological sensing: The role of the electrode impedance

Biscarini F.;Gomes H. L.
2016

Abstract

Conducting polymer electrodes based on poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) are used to record extracellular signals from autonomous cardiac contractile cells and glioma cell cultures. The performance of these conducting polymer electrodes is compared with Au electrodes. A small-signal impedance analysis shows that in the presence of an electrolyte, both Au and polymer electrodes establish high capacitive double-layers. However, the polymer/electrolyte interfacial resistance is 3 orders of magnitude lower than the resistance of the metal/electrolyte interface. The polymer low interfacial resistance minimizes the intrinsic thermal noise and increases the system sensitivity. However, when measurements are carried out in current mode a low interfacial resistance partially acts as a short circuit of the interfacial capacitance, this affects the signal shape.
2016
Organic Sensors and Bioelectronics IX
usa
2016
9944
994404
Medeiros, M. C. R.; Mestre, A. L. G.; Inacio, P. M. C.; Santos, J. M. L.; Araujo, I. M.; Braganca, J.; Biscarini, F.; Gomes, H. L.
Performance assessment of polymer based electrodes for in vitro electrophysiological sensing: The role of the electrode impedance / Medeiros, M. C. R.; Mestre, A. L. G.; Inacio, P. M. C.; Santos, J. M. L.; Araujo, I. M.; Braganca, J.; Biscarini, F.; Gomes, H. L.. - 9944:(2016), p. 994404. (Intervento presentato al convegno Organic Sensors and Bioelectronics IX tenutosi a usa nel 2016) [10.1117/12.2237659].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1222664
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