Cerebrospinal fluid (CSF) kappa free light chains (KFLC) are gaining increasing interest as markers of intrathecal immunoglobulin synthesis. The main aim of this study was to assess the diagnostic accuracy (AUC) of the kappa index (CSF/serum KFLC divided by the CSF/serum albumin ratio) compared to CSF oligoclonal IgG bands (OCB) in predicting Multiple Sclerosis (MS) or a central nervous system infectious/inflammatory disorder (CNSID).
Kappa Index Versus CSF Oligoclonal Bands in Predicting Multiple Sclerosis and Infectious/Inflammatory CNS Disorders / Ferraro, Diana; Bedin, Roberta; Natali, Patrizia; Franciotta, Diego; Smolik, Krzysztof; Santangelo, Mario; Immovilli, Paolo; Camera, Valentina; Vitetta, Francesca; Gastaldi, Matteo; Trenti, Tommaso; Meletti, Stefano; Sola, Patrizia. - In: DIAGNOSTICS. - ISSN 2075-4418. - 10:10(2020), pp. 000-011. [10.3390/diagnostics10100856]
Kappa Index Versus CSF Oligoclonal Bands in Predicting Multiple Sclerosis and Infectious/Inflammatory CNS Disorders
Ferraro, Diana
;Bedin, Roberta;Camera, Valentina;Meletti, Stefano;
2020
Abstract
Cerebrospinal fluid (CSF) kappa free light chains (KFLC) are gaining increasing interest as markers of intrathecal immunoglobulin synthesis. The main aim of this study was to assess the diagnostic accuracy (AUC) of the kappa index (CSF/serum KFLC divided by the CSF/serum albumin ratio) compared to CSF oligoclonal IgG bands (OCB) in predicting Multiple Sclerosis (MS) or a central nervous system infectious/inflammatory disorder (CNSID).
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