We uncovered a role for nucleoli and PML-bodies as phase-separated protein quality control organelles that compartmentalize protein quality control factors and misfolded proteins for their efficient clearance. Failure to dispose misfolded proteins converts nucleoli and PML-bodies into a solid state that immobilizes ubiquitin, limiting its recycling for genome integrity maintenance.
Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins / Mediani, L.; Guillen-Boixet, J.; Alberti, S.; Carra, S.. - In: MOLECULAR & CELLULAR ONCOLOGY. - ISSN 2372-3556. - 6:6(2019), pp. e1415624-e. [10.1080/23723556.2019.1652519]
Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins
Mediani L.;Carra S.
2019
Abstract
We uncovered a role for nucleoli and PML-bodies as phase-separated protein quality control organelles that compartmentalize protein quality control factors and misfolded proteins for their efficient clearance. Failure to dispose misfolded proteins converts nucleoli and PML-bodies into a solid state that immobilizes ubiquitin, limiting its recycling for genome integrity maintenance.
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Nucleoli and Promyelocytic Leukemia Protein PML bodies are phase separated nuclear protein quality control compartments for misfolded proteins.pdf
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