A definite association between the transcription of N-myc oncogene and proliferation-related genes, histone H3, c-myc and p53, was found in a set of 12 primary untreated neuroblastomas and a metastasis of one of these at relapse. Molecular analysis allowed us to discriminate between actually proliferating and non-proliferating tumors, and suggested a link between N-myc and proliferation. Flow cytometric analysis of DNA distribution was less reliable for assessing tumor proliferative activity. Our data also seem to indicate a down-regulation of c-myc by N-myc in human neuroblastoma.
TRANSCRIPTION OF N-MYC AND PROLIFERATION-RELATED GENES IS LINKED IN HUMAN NEUROBLASTOMA / Raschella, G; Negroni, A; Giubilei, C; Romeo, A; Ferrari, Sergio; Castello, Ma; Dominici, C.. - In: CANCER LETTERS. - ISSN 0304-3835. - STAMPA. - 56:(1991), pp. 45-51.
TRANSCRIPTION OF N-MYC AND PROLIFERATION-RELATED GENES IS LINKED IN HUMAN NEUROBLASTOMA
FERRARI, Sergio;
1991
Abstract
A definite association between the transcription of N-myc oncogene and proliferation-related genes, histone H3, c-myc and p53, was found in a set of 12 primary untreated neuroblastomas and a metastasis of one of these at relapse. Molecular analysis allowed us to discriminate between actually proliferating and non-proliferating tumors, and suggested a link between N-myc and proliferation. Flow cytometric analysis of DNA distribution was less reliable for assessing tumor proliferative activity. Our data also seem to indicate a down-regulation of c-myc by N-myc in human neuroblastoma.
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