“Real-time” Assessment of Surgical Margins During Radical Prostatectomy: State-of-the-Art

Eissa, A.; Zoeir, A.; Sighinolfi, M. C.; Puliatti, S.; Bevilacqua, L.; Del Prete, C.; Bertoni, L.; Azzoni, P.; Reggiani Bonetti, L.; Micali, S.; Bianchi, G.; Rocco, B.

doi:10.1016/j.clgc.2019.07.012

Histopathologic examination of the pathologic specimens using hematoxylin & eosin stains represents the backbone of the modern pathology. It is time-consuming; thus, “real-time” assessment of prostatic and periprostatic tissue has gained special interest in the diagnosis and management of prostate cancer. The current study focuses on the review of the different available techniques for “real-time” evaluation of surgical margins during radical prostatectomy (RP). We performed a comprehensive search of the Medline database to identify all the articles discussing “real-time” or intraoperative assessment of surgical margins during RP. Several filters were applied to the search to include only English articles performed on human subjects and published between January 2000 and March 2019. The search revealed several options for pathologic assessment of surgical margins including intraoperative frozen sections, confocal laser endomicroscopy, optical spectroscopy, photodynamic diagnosis, optical coherence tomography, multiphoton microscopy, structured illumination microscopy, 3D augmented reality, and ex vivo fluorescence confocal microscope. Frozen section represents the gold standard technique for real-time pathologic examinations of surgical margins during RP; however, several other options showed promising results in the initial clinical trials, and considering the rapid development in the field of molecular and cellular imaging, some of these options may serve as an alternative to frozen section.

“Real-time” Assessment of Surgical Margins During Radical Prostatectomy: State-of-the-Art / Eissa, A.; Zoeir, A.; Sighinolfi, M. C.; Puliatti, S.; Bevilacqua, L.; Del Prete, C.; Bertoni, L.; Azzoni, P.; Reggiani Bonetti, L.; Micali, S.; Bianchi, G.; Rocco, B.. - In: CLINICAL GENITOURINARY CANCER. - ISSN 1558-7673. - 18:2(2020), pp. 95-104.

Data di pubblicazione:	2020
Data di prima pubblicazione:	19-lug-2019
Titolo:	“Real-time” Assessment of Surgical Margins During Radical Prostatectomy: State-of-the-Art
Autore/i:	Eissa, A.; Zoeir, A.; Sighinolfi, M. C.; Puliatti, S.; Bevilacqua, L.; Del Prete, C.; Bertoni, L.; Azzoni, P.; Reggiani Bonetti, L.; Micali, S.; Bianchi, G.; Rocco, B.
Autore/i UNIMORE:	Eissa A. Zoeir A. SIGHINOLFI, Maria Chiara Puliatti, Stefano Bevilacqua, Luigi DEL PRETE, CHIARA BERTONI, Laura AZZONI, Paola REGGIANI BONETTI, Luca MICALI, Salvatore BIANCHI, Giampaolo ROCCO, Bernardo Maria Cesare mostra contributor esterni nascondi contributor esterni
Digital Object Identifier (DOI):	http://dx.doi.org/10.1016/j.clgc.2019.07.012
Rivista:	CLINICAL GENITOURINARY CANCER
Volume:	18
Fascicolo:	2
Pagina iniziale:	95
Pagina finale:	104
Codice identificativo ISI:	WOS:000523650600021
Codice identificativo Scopus:	2-s2.0-85076561254
Codice identificativo Pubmed:	31784282
Citazione:	“Real-time” Assessment of Surgical Margins During Radical Prostatectomy: State-of-the-Art / Eissa, A.; Zoeir, A.; Sighinolfi, M. C.; Puliatti, S.; Bevilacqua, L.; Del Prete, C.; Bertoni, L.; Azzoni, P.; Reggiani Bonetti, L.; Micali, S.; Bianchi, G.; Rocco, B.. - In: CLINICAL GENITOURINARY CANCER. - ISSN 1558-7673. - 18:2(2020), pp. 95-104.
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