A method is described for calculating the binding parameters of a drug to a macromolecule from data obtained by indirect techniques, such as spectroscopy, assuming the existence of only one class of binding sites. A critical evaluation of the performance of the method is presented, showing that the errors which previously reported methods may produce are avoided. Some examples that make use of experimental data determined for phenylbutazone and oxyphenbutazone by means of UV difference spectroscopy are given.

DETERMINATION OF DRUG - MACROMOLECULE BINDING PARAMETERS BY NUMERICAL-ANALYSIS / Cevolani, M; Costantino, Luca; Albasini, A.. - In: ANALYTICA CHIMICA ACTA. - ISSN 0003-2670. - STAMPA. - 244:(1991), pp. 145-149.

DETERMINATION OF DRUG - MACROMOLECULE BINDING PARAMETERS BY NUMERICAL-ANALYSIS

COSTANTINO, Luca;
1991

Abstract

A method is described for calculating the binding parameters of a drug to a macromolecule from data obtained by indirect techniques, such as spectroscopy, assuming the existence of only one class of binding sites. A critical evaluation of the performance of the method is presented, showing that the errors which previously reported methods may produce are avoided. Some examples that make use of experimental data determined for phenylbutazone and oxyphenbutazone by means of UV difference spectroscopy are given.
244
145
149
DETERMINATION OF DRUG - MACROMOLECULE BINDING PARAMETERS BY NUMERICAL-ANALYSIS / Cevolani, M; Costantino, Luca; Albasini, A.. - In: ANALYTICA CHIMICA ACTA. - ISSN 0003-2670. - STAMPA. - 244:(1991), pp. 145-149.
Cevolani, M; Costantino, Luca; Albasini, A.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/12137
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact