Electrical pulses were applied to the distal femur of rabbits by inserting four electrodes in order to evaluate if and to what extent cell electroporation could be achieved in such a non-homogenous tissue. Dose response effect of number of pulses delivered was observed. 120 pulses at 1750V/cm successfully removed all osteogenetic activity among the electrodes, as evidenced by tetracyclin staining. These preclinical results lay the foundation for use of electroporation in the treatment of bone metastases. © 2009 Springer-Verlag.
Electroporation of bone tissue: Implications for use in the treatment of bone metastasis with electrochemotherapy / Cadossi, R.; Fini, M.; Ronchetti, M.; De Terlizzi, F.; Cavani, F.. - In: IFMBE PROCEEDINGS (CD). - ISSN 1727-1983. - 25:13(2009), pp. 8-9. (Intervento presentato al convegno World Congress on Medical Physics and Biomedical Engineering: Special Topics and Workshops tenutosi a Munich, deu nel 2009) [10.1007/978-3-642-03895-2_3].
Electroporation of bone tissue: Implications for use in the treatment of bone metastasis with electrochemotherapy
Ronchetti M.;Cavani F.
2009
Abstract
Electrical pulses were applied to the distal femur of rabbits by inserting four electrodes in order to evaluate if and to what extent cell electroporation could be achieved in such a non-homogenous tissue. Dose response effect of number of pulses delivered was observed. 120 pulses at 1750V/cm successfully removed all osteogenetic activity among the electrodes, as evidenced by tetracyclin staining. These preclinical results lay the foundation for use of electroporation in the treatment of bone metastases. © 2009 Springer-Verlag.
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