Pneumonia is the most frequent complication of COVID-19, due to an aberrant host immune response that is associated with an acute respiratory distress syndrome, and, in most critical patients, with a "cytokine storm". IL-6 might play a key role in the cytokine storm and might be a potential target to treat severe and critical COVID-19. Tocilizumab is a recombinant humanized monoclonal antibody, directed against IL-6 receptor.
TOCIVID-19 - A multicenter study on the efficacy and tolerability of tocilizumab in the treatment of patients with COVID-19 pneumonia. Study protocol / Piccirillo, Maria Carmela; Ascierto, Paolo; Atripaldi, Luigi; Cascella, Marco; Costantini, Massimo; Dolci, Giovanni; Facciolongo, Nicola; Fraganza, Fiorentino; Marata, AnnaMaria; Massari, Marco; Montesarchio, Vincenzo; Mussini, Cristina; Negri, Emanuele Alberto; Parrella, Roberto; Popoli, Patrizia; Botti, Gerardo; Arenare, Laura; Chiodini, Paolo; Gallo, Ciro; Salvarani, Carlo; Perrone, Francesco. - In: CONTEMPORARY CLINICAL TRIALS. - ISSN 1551-7144. - 98:(2020), pp. 106165-106165. [10.1016/j.cct.2020.106165]
TOCIVID-19 - A multicenter study on the efficacy and tolerability of tocilizumab in the treatment of patients with COVID-19 pneumonia. Study protocol
Dolci, Giovanni;Mussini, Cristina;Salvarani, Carlo;Perrone, Francesco
2020
Abstract
Pneumonia is the most frequent complication of COVID-19, due to an aberrant host immune response that is associated with an acute respiratory distress syndrome, and, in most critical patients, with a "cytokine storm". IL-6 might play a key role in the cytokine storm and might be a potential target to treat severe and critical COVID-19. Tocilizumab is a recombinant humanized monoclonal antibody, directed against IL-6 receptor.
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