Liver disease is an important cause of morbidity and mortality in people living with HIV (PLWH), of which non-alcoholic fatty liver disease (NAFLD) is an increasingly recognised cause. There is limited data investigating NAFLD in HIV mono-infection and histologically defined disease. We aimed to identify who is at risk of fibrosis, NAFLD and NASH among PLWH, and explore the diagnostic accuracy of non-invasive markers of fibrosis.
Increased BMI and Type 2 diabetes are the main predictors of NAFLD and advanced fibrosis in liver biopsies of patients with HIV mono-infection / Maurice, James B; Goldin, Robert; Hall, Andrew; Price, Jennifer C; Sebastiani, Giada; Morse, Caryn G; Prat, Laura; Perazzo, Hugo; Garvey, Lucy; Ingiliz, Patrick; Guaraldi, Giovanni; Tsochatzis, Emmanouil; Lemoine, Maud. - In: CLINICAL INFECTIOUS DISEASES. - ISSN 1058-4838. - 73:7(2021), pp. e2184-e2193. [10.1093/cid/ciaa1302]
Increased BMI and Type 2 diabetes are the main predictors of NAFLD and advanced fibrosis in liver biopsies of patients with HIV mono-infection
Guaraldi, Giovanni;
2021
Abstract
Liver disease is an important cause of morbidity and mortality in people living with HIV (PLWH), of which non-alcoholic fatty liver disease (NAFLD) is an increasingly recognised cause. There is limited data investigating NAFLD in HIV mono-infection and histologically defined disease. We aimed to identify who is at risk of fibrosis, NAFLD and NASH among PLWH, and explore the diagnostic accuracy of non-invasive markers of fibrosis.
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