Stress is a typical body's natural defense to a generic physical or psychic change. A specific linking mechanism between ulcer onset and psycho-physical stress prolonged exposure has been reported. We decided to investigate the possible effects of Borago officinalis L. (Borago) in preventing physical (stress)-induced gastric ulcers in a rat model. Eighty male Sprague-Dawley rats were randomly divided into 16 groups, pretreated with a control solution, omeprazole (20 mg/kg), Borago methanolic extract (25, 50, 100, 250, and 500 mg/kg), Borago organic extract (50, 100, 250, and 500 mg/kg), Borago aqueous extract (5, 10, 20, 30, and 40 mg/kg), and D(-)-2-Amino-5-phosphonovaleric acid (AP5) (25 mg/kg) and kept in stressful conditions such as water immersion and restraint-induced stress ulcers. The animals were sacrificed and their stomach scored for the severity and the number of gastric ulcers. Methanolic extract (500 mg/kg) significantly reduced both ulcer parameters (***p < 0.001 and **p < 0.01, respectively). Aqueous and organic extract significantly decreased severity score at 5 and 10 mg/kg (**p < 0.01 and ***p < 0.001, respectively), and at 250 and 500 mg/kg (***p < 0.001), respectively, while gastric ulcers' resulted number significantly reduced only at 10 mg/kg (*p < 0.05) and at 500 mg/kg (**p < 0.01), respectively. On the other hand, aqueous extract significantly increased the mucosal gastric content of cAMP (*p < 0.05) and NR2A and NR2B subunits (*p < 0.05 and **p < 0.01, respectively) at 5 mg/kg. Organic extract showed also a significant cytotoxic effect at 500 and 1,000 mg/kg with a 3T3 cell viability reduction of 43.6% (**p < 0.01) and 92.1% (***p < 0.001), respectively. Borago aqueous extract at 10 mg/kg could be considered as a potential protective agent against stress-induced ulcers, and it is reasonable to possibly ascribe such protective activity to a modulation of the NR2A and NR2B subunit expression.
Protective Effects of Borago officinalis (Borago) on Cold Restraint Stress-Induced Gastric Ulcers in Rats: A Pilot Study / Di Cerbo, Alessandro; Carnevale, Gianluca; Avallone, Rossella; Zavatti, Manuela; Corsi, Lorenzo. - In: FRONTIERS IN VETERINARY SCIENCE. - ISSN 2297-1769. - (2020), pp. 1-9.
Data di pubblicazione: | 2020 |
Data di prima pubblicazione: | set-2020 |
Titolo: | Protective Effects of Borago officinalis (Borago) on Cold Restraint Stress-Induced Gastric Ulcers in Rats: A Pilot Study |
Autore/i: | Di Cerbo, Alessandro; Carnevale, Gianluca; Avallone, Rossella; Zavatti, Manuela; Corsi, Lorenzo |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.3389/fvets.2020.00427 |
Rivista: | |
Pagina iniziale: | 1 |
Pagina finale: | 9 |
Codice identificativo ISI: | WOS:000570430300001 |
Codice identificativo Scopus: | 2-s2.0-85090932724 |
Codice identificativo Pubmed: | 32984407 |
Citazione: | Protective Effects of Borago officinalis (Borago) on Cold Restraint Stress-Induced Gastric Ulcers in Rats: A Pilot Study / Di Cerbo, Alessandro; Carnevale, Gianluca; Avallone, Rossella; Zavatti, Manuela; Corsi, Lorenzo. - In: FRONTIERS IN VETERINARY SCIENCE. - ISSN 2297-1769. - (2020), pp. 1-9. |
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