Background: Pulmonary sclerosing pneumocytoma (PSP) is a rare benign pulmonary tumor that derives from primitive respiratory epithelium of the pulmonary alveolus. The etiology and pathogenesis are still unclear. Histopathological diagnosis focuses on cells that are positive for TTF1, EMA, cytokeratin-7, and CAM 5.2. The aim of our study is to highlight the elevated expression of ALDH and the presence of SOX-2 in pulmonary sclerosing pneumocytoma. Methods: We report five cases of pulmonary sclerosing pneumocytoma undergone surgery at our Division of Thoracic Surgery, during a period between 1994 and 2011. ALDH and SOX-2 markers were also tested for positivity in all the patients. Results: Patients showed elevated expression of ALDH during immunohistochemistry and mild expression of SOX-2, although in two cases in which SOX-2 was highly expressed. Among these two patients, one presented with lymph node recurrence while the other had no recurrence with a PET-positive nodule. In particular, the patient who had developed recurrence had an ALDH score of 4 and a SOX-2 score of 3, whereas the patient with the PET-positive nodule showed an ALDH score of 4 with a mild SOX-2expression of score 1. Conclusions: This is the first attempt demonstrating the elevated expression of ALDH in this disease. SOX-2 expression was noted in both the patient who developed recurrence and the patient with a PET-positive nodule. We believe that further investigation may be highly useful to better characterize these two markers as well as understandtheir function.

Expression of ALDH and SOX-2 in Pulmonary Sclerosing Pnemocytoma (PSP) of the Lung: Is There a Meaning Behind? / Aramini, Beatrice; Masciale, Valentina; Manfredini, Beatrice; Bianchi, Daniel; Banchelli, Federico; D'Amico, Roberto; Bertolini, Federica; Dominici, Massimo; Morandi, Uliano; Maiorana, Antonino. - In: FRONTIERS IN MEDICINE. - ISSN 2296-858X. - 7:(2020), pp. 1-7. [10.3389/fmed.2020.00497]

Expression of ALDH and SOX-2 in Pulmonary Sclerosing Pnemocytoma (PSP) of the Lung: Is There a Meaning Behind?

Beatrice Aramini
Writing – Original Draft Preparation
;
Valentina Masciale
Methodology
;
Beatrice Manfredini;Daniel Bianchi
Resources
;
Federico Banchelli
Formal Analysis
;
Roberto D’Amico
Formal Analysis
;
Federica Bertolini
Validation
;
Massimo Dominici
Investigation
;
Uliano Morandi
Supervision
;
Antonino Maiorana
Writing – Review & Editing
2020

Abstract

Background: Pulmonary sclerosing pneumocytoma (PSP) is a rare benign pulmonary tumor that derives from primitive respiratory epithelium of the pulmonary alveolus. The etiology and pathogenesis are still unclear. Histopathological diagnosis focuses on cells that are positive for TTF1, EMA, cytokeratin-7, and CAM 5.2. The aim of our study is to highlight the elevated expression of ALDH and the presence of SOX-2 in pulmonary sclerosing pneumocytoma. Methods: We report five cases of pulmonary sclerosing pneumocytoma undergone surgery at our Division of Thoracic Surgery, during a period between 1994 and 2011. ALDH and SOX-2 markers were also tested for positivity in all the patients. Results: Patients showed elevated expression of ALDH during immunohistochemistry and mild expression of SOX-2, although in two cases in which SOX-2 was highly expressed. Among these two patients, one presented with lymph node recurrence while the other had no recurrence with a PET-positive nodule. In particular, the patient who had developed recurrence had an ALDH score of 4 and a SOX-2 score of 3, whereas the patient with the PET-positive nodule showed an ALDH score of 4 with a mild SOX-2expression of score 1. Conclusions: This is the first attempt demonstrating the elevated expression of ALDH in this disease. SOX-2 expression was noted in both the patient who developed recurrence and the patient with a PET-positive nodule. We believe that further investigation may be highly useful to better characterize these two markers as well as understandtheir function.
2020
7
1
7
Expression of ALDH and SOX-2 in Pulmonary Sclerosing Pnemocytoma (PSP) of the Lung: Is There a Meaning Behind? / Aramini, Beatrice; Masciale, Valentina; Manfredini, Beatrice; Bianchi, Daniel; Banchelli, Federico; D'Amico, Roberto; Bertolini, Federica; Dominici, Massimo; Morandi, Uliano; Maiorana, Antonino. - In: FRONTIERS IN MEDICINE. - ISSN 2296-858X. - 7:(2020), pp. 1-7. [10.3389/fmed.2020.00497]
Aramini, Beatrice; Masciale, Valentina; Manfredini, Beatrice; Bianchi, Daniel; Banchelli, Federico; D'Amico, Roberto; Bertolini, Federica; Dominici, M...espandi
File in questo prodotto:
File Dimensione Formato  
Beatrice Aramini 2020.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 849.53 kB
Formato Adobe PDF
849.53 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1209030
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact