This chapter provides a comprehensive description of the physical, chemical, biological and mineralogical parameters that play a role in determining the toxicity and pathogenicity of mineral fibres. The first steps towards a general toxicity/pathogenicity model of mineral fibres are described here. Eventually the model can be generalized and may be applied to biodurable man-made mineral fibres and other natural and synthetic fibres in addition to silicates. Because of the complexity of the topic, a truly multidisciplinary approach is essential. A concept that will be stressed in the final notes of the chapter is that a full understanding of the toxicity/pathogenicity of mineral fibres aimed at finding effective solutions for the prevention and treatment of asbestos-related diseases can only be the outcome if an holistic approach is applied which takes advantage of synergistic research activity and communication between biochemists, mineralogists/crystallographers, pathologists, physicians, physicists and toxicologists, all sharing their distinct but interrelated perspectives. This is a great challenge for all such scientific individuals to work together to resolve and develop predictive models that incorporate their research findings and conclusions.

Towards a general model for predicting the toxicity and pathogenicity of mineral fibres / Gualtieri, A. F.; Mossman, B. T.; Roggli, V. L.. - 18:(2017), pp. 501-532. [10.1180/EMU-notes.18.15]

Towards a general model for predicting the toxicity and pathogenicity of mineral fibres

Gualtieri A. F.;
2017

Abstract

This chapter provides a comprehensive description of the physical, chemical, biological and mineralogical parameters that play a role in determining the toxicity and pathogenicity of mineral fibres. The first steps towards a general toxicity/pathogenicity model of mineral fibres are described here. Eventually the model can be generalized and may be applied to biodurable man-made mineral fibres and other natural and synthetic fibres in addition to silicates. Because of the complexity of the topic, a truly multidisciplinary approach is essential. A concept that will be stressed in the final notes of the chapter is that a full understanding of the toxicity/pathogenicity of mineral fibres aimed at finding effective solutions for the prevention and treatment of asbestos-related diseases can only be the outcome if an holistic approach is applied which takes advantage of synergistic research activity and communication between biochemists, mineralogists/crystallographers, pathologists, physicians, physicists and toxicologists, all sharing their distinct but interrelated perspectives. This is a great challenge for all such scientific individuals to work together to resolve and develop predictive models that incorporate their research findings and conclusions.
2017
Mineral fibres: crystal chemistry, chemical-physical properties, biological interaction and toxicity
GUALTIERI, Alessandro
9780903056656
European Mineralogical Union
REGNO UNITO DI GRAN BRETAGNA
Towards a general model for predicting the toxicity and pathogenicity of mineral fibres / Gualtieri, A. F.; Mossman, B. T.; Roggli, V. L.. - 18:(2017), pp. 501-532. [10.1180/EMU-notes.18.15]
Gualtieri, A. F.; Mossman, B. T.; Roggli, V. L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1208887
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