Vascular calcification (VC), characterized by different mineral deposits (i.e., carbonate apatite, whitlockite and hydroxyapatite) accumulating in blood vessels and valves, represents a relevant pathological process for the aging population and a life-threatening complication in acquired and in genetic diseases. Similarly to bone remodeling, VC is an actively regulated process in which many cells and molecules play a pivotal role. This review aims at: (i) describing the role of resident and circulating cells, of the extracellular environment and of positive and negative factors in driving the mineralization process; (ii) detailing the types of VC (i.e., intimal, medial and cardiac valve calcification); (iii) analyzing rare genetic diseases underlining the importance of altered pyrophosphate-dependent regulatory mechanisms; (iv) providing therapeutic options and perspectives.
The biology of vascular calcification / Quaglino, D.; Boraldi, F.; Lofaro, F. D.. - 354(2020), pp. 261-353.
Data di pubblicazione: | 2020 |
Titolo: | The biology of vascular calcification |
Autore/i: | Quaglino, D.; Boraldi, F.; Lofaro, F. D. |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/bs.ircmb.2020.02.007 |
Codice identificativo Scopus: | 2-s2.0-85082714249 |
Codice identificativo ISI: | WOS:000611914400008 |
Codice identificativo Pubmed: | 32475476 |
Serie: | INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY |
Titolo del libro: | International Review of Cell and Molecular Biology |
ISBN: | 9780128199275 |
Editore: | Elsevier Inc. |
Citazione: | The biology of vascular calcification / Quaglino, D.; Boraldi, F.; Lofaro, F. D.. - 354(2020), pp. 261-353. |
Data di prima pubblicazione: | 6-apr-2020 |
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