Vascular calcification (VC), characterized by different mineral deposits (i.e., carbonate apatite, whitlockite and hydroxyapatite) accumulating in blood vessels and valves, represents a relevant pathological process for the aging population and a life-threatening complication in acquired and in genetic diseases. Similarly to bone remodeling, VC is an actively regulated process in which many cells and molecules play a pivotal role. This review aims at: (i) describing the role of resident and circulating cells, of the extracellular environment and of positive and negative factors in driving the mineralization process; (ii) detailing the types of VC (i.e., intimal, medial and cardiac valve calcification); (iii) analyzing rare genetic diseases underlining the importance of altered pyrophosphate-dependent regulatory mechanisms; (iv) providing therapeutic options and perspectives.

The biology of vascular calcification / Quaglino, D.; Boraldi, F.; Lofaro, F. D.. - 354(2020), pp. 261-353. [10.1016/bs.ircmb.2020.02.007]

The biology of vascular calcification

Quaglino D.;Boraldi F.;Lofaro F. D.
2020

Abstract

Vascular calcification (VC), characterized by different mineral deposits (i.e., carbonate apatite, whitlockite and hydroxyapatite) accumulating in blood vessels and valves, represents a relevant pathological process for the aging population and a life-threatening complication in acquired and in genetic diseases. Similarly to bone remodeling, VC is an actively regulated process in which many cells and molecules play a pivotal role. This review aims at: (i) describing the role of resident and circulating cells, of the extracellular environment and of positive and negative factors in driving the mineralization process; (ii) detailing the types of VC (i.e., intimal, medial and cardiac valve calcification); (iii) analyzing rare genetic diseases underlining the importance of altered pyrophosphate-dependent regulatory mechanisms; (iv) providing therapeutic options and perspectives.
6-apr-2020
International Review of Cell and Molecular Biology
9780128199275
Elsevier Inc.
The biology of vascular calcification / Quaglino, D.; Boraldi, F.; Lofaro, F. D.. - 354(2020), pp. 261-353. [10.1016/bs.ircmb.2020.02.007]
Quaglino, D.; Boraldi, F.; Lofaro, F. D.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1208726
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