Purpose: Triple therapy with steroids, vitamin C and thiamine has been recently proposed as a safe and beneficial in patients with sepsis. In 2017, we added the use of intravenous vitamin C and thiamine in septic shock patients receiving low dose hydrocortisone because poorly responsive to vasopressors. Aim of this study is to verify whether triple therapy rather than steroids alone can improve outcome in patients with refractory shock. Materials and methods: In this before-after retrospective analysis, we compared septic shock patients admitted to our intensive care unit (ICU) who received triple therapy from June 2017 to November 2019 to septic shock patients who received only hydrocortisone from January 2015 to June 2017. Patients of the two study periods were matched 1:1 using a propensity score model. Results: A final cohort of 56 patients treated with triple therapy were matched to 56 patients treated only with steroids. Triple therapy reduced the length of mechanical ventilation (p = 0,01) and showed a trend in lowering the 30-day and hospital mortality compared to therapy with only hydrocortisone. Conclusions: Although with significant limitations, our experience indicated that triple therapy seems to provide an improvement of clinical outcomes in patients with refractory septic shock.

Adjunctive therapy with vitamin c and thiamine in patients treated with steroids for refractory septic shock: A propensity matched before-after, case-control study / Coloretti, I.; Biagioni, E.; Venturelli, S.; Munari, E.; Tosi, M.; Roat, E.; Brugioni, L.; Gelmini, R.; Venturelli, C.; Girardis, M.. - In: JOURNAL OF CRITICAL CARE. - ISSN 0883-9441. - 59:(2020), pp. 37-41. [10.1016/j.jcrc.2020.04.014]

Adjunctive therapy with vitamin c and thiamine in patients treated with steroids for refractory septic shock: A propensity matched before-after, case-control study

Coloretti I.;Biagioni E.;Venturelli S.;Munari E.;Tosi M.;Roat E.;Gelmini R.;Venturelli C.;Girardis M.
2020

Abstract

Purpose: Triple therapy with steroids, vitamin C and thiamine has been recently proposed as a safe and beneficial in patients with sepsis. In 2017, we added the use of intravenous vitamin C and thiamine in septic shock patients receiving low dose hydrocortisone because poorly responsive to vasopressors. Aim of this study is to verify whether triple therapy rather than steroids alone can improve outcome in patients with refractory shock. Materials and methods: In this before-after retrospective analysis, we compared septic shock patients admitted to our intensive care unit (ICU) who received triple therapy from June 2017 to November 2019 to septic shock patients who received only hydrocortisone from January 2015 to June 2017. Patients of the two study periods were matched 1:1 using a propensity score model. Results: A final cohort of 56 patients treated with triple therapy were matched to 56 patients treated only with steroids. Triple therapy reduced the length of mechanical ventilation (p = 0,01) and showed a trend in lowering the 30-day and hospital mortality compared to therapy with only hydrocortisone. Conclusions: Although with significant limitations, our experience indicated that triple therapy seems to provide an improvement of clinical outcomes in patients with refractory septic shock.
5-mag-2020
59
37
41
Adjunctive therapy with vitamin c and thiamine in patients treated with steroids for refractory septic shock: A propensity matched before-after, case-control study / Coloretti, I.; Biagioni, E.; Venturelli, S.; Munari, E.; Tosi, M.; Roat, E.; Brugioni, L.; Gelmini, R.; Venturelli, C.; Girardis, M.. - In: JOURNAL OF CRITICAL CARE. - ISSN 0883-9441. - 59:(2020), pp. 37-41. [10.1016/j.jcrc.2020.04.014]
Coloretti, I.; Biagioni, E.; Venturelli, S.; Munari, E.; Tosi, M.; Roat, E.; Brugioni, L.; Gelmini, R.; Venturelli, C.; Girardis, M.
File in questo prodotto:
File Dimensione Formato  
JCRITICALCARE2020.pdf

accesso aperto

Descrizione: articolo principale
Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 422.84 kB
Formato Adobe PDF
422.84 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1208643
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 11
social impact