The type of DNA damage and the role of poly(ADP-ribosyl)polymerase (ADPRP) and sulphated glyprotein 2 (SGP-2) in programmed cell death (apoptosis) was investigated in the following model systems: i) rat thymocytes treated with dexamethasone (DEX) either in vitro or in vivo; ii) human perypheral blood mononuclear cells (hPBMCs) exposed to oxygen free radicals (OR); iii) K562 cell line killed by hPBMCs during spontaneous (NK) or interleukin-2 (IL-2)-induced (LAK) cytotoxic activity. The results suggest that ADPRP and SGP-2 are involved in the apoptotic process, but their role probably differs according to the type of cell and the inducing damage/stimulus. Moreover, no simple correlation appears to exist between the extent of DNA damage and cell survival or cell death.
DNA AND CELL-DEATH / Monti, D; Troiano, L; Tropea, F; Grassilli, E; Cossarizza, Andrea; Barozzi, D; Bettuzzi, S; Corti, Arnaldo; Franceschi, C.. - In: CYTOTECHNOLOGY. - ISSN 0920-9069. - 5:(1991), pp. 74-77.
DNA AND CELL-DEATH
COSSARIZZA, Andrea;CORTI, Arnaldo;
1991
Abstract
The type of DNA damage and the role of poly(ADP-ribosyl)polymerase (ADPRP) and sulphated glyprotein 2 (SGP-2) in programmed cell death (apoptosis) was investigated in the following model systems: i) rat thymocytes treated with dexamethasone (DEX) either in vitro or in vivo; ii) human perypheral blood mononuclear cells (hPBMCs) exposed to oxygen free radicals (OR); iii) K562 cell line killed by hPBMCs during spontaneous (NK) or interleukin-2 (IL-2)-induced (LAK) cytotoxic activity. The results suggest that ADPRP and SGP-2 are involved in the apoptotic process, but their role probably differs according to the type of cell and the inducing damage/stimulus. Moreover, no simple correlation appears to exist between the extent of DNA damage and cell survival or cell death.
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