We reported two fatal cases of acute liver failure secondary to Herpes Simplex Virus 1 infection in COVID-19 patients, following tocilizumab and corticosteroid therapy. Screening for and prompt recognition of Herpes Simplex Virus 1 reactivation in these patients, undergoing immunomodulatory treatment, may have potentially relevant clinical consequences.
Two fatal cases of acute liver failure due to HSV-1 infection in COVID-19 patients following immunomodulatory therapies / Busani, S; Bedini, A; Biagioni, E; Serio, L; Tonelli, R; Meschiari, M; Franceschini, E; Guaraldi, G; Cossarizza, A; Clini, E; Maiorana, A; Gennari, W; De Maria, N; Luppi, M; Mussini, C; Girardis, M.; Gibellini, Lara. - In: CLINICAL INFECTIOUS DISEASES. - ISSN 1058-4838. - 73:1(2021), pp. 252-255. [10.1093/cid/ciaa1246]
Two fatal cases of acute liver failure due to HSV-1 infection in COVID-19 patients following immunomodulatory therapies.
Busani, S
;Bedini, A;Biagioni, E;Tonelli, R;Meschiari, M;Franceschini, E;Guaraldi, G;Cossarizza, A;Clini, E;Maiorana, A;Luppi, M;Mussini, C;Girardis, M.;Gibellini, lara
2021
Abstract
We reported two fatal cases of acute liver failure secondary to Herpes Simplex Virus 1 infection in COVID-19 patients, following tocilizumab and corticosteroid therapy. Screening for and prompt recognition of Herpes Simplex Virus 1 reactivation in these patients, undergoing immunomodulatory treatment, may have potentially relevant clinical consequences.
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