Frequency and Results of Cryoglobulin Retesting in 4,963 Patients: Comment on the Article by Kolopp-Sarda et al

Cryoglobulinemia is a rare pathology which is difficult to diagnose both clinically and in the laboratory. Symptoms vary and there are many difficulties in the detection of cryoglobulins (CRG), beginning with the necessity of maintaining the sample at 37°C during the pre‐analytic phase until centrifugation in laboratory. To improve analytical accuracy, some authors have suggested the repetition of sample examinations, especially with persistent clinical suspicion, to avoid false‐negative results.