Thirteen Non-Conventional Yeasts (NCYs) have been investigated for their ability to reduce activated C=C bonds of chalcones to obtain the corresponding dihydrochalcones. A possible correlation between bioreducing capacity of the NCYs and the substrate structure was estimated. Generally, whole-cells of the NCYs were able to hydrogenate the C=C double bond occurring in (E)-1,3-diphenylprop-2-en-1-one, while worthy bioconversion yields were obtained when the substrate exhibited the presence of a deactivating electron-withdrawing Cl substituent on the B-ring. On the contrary, no conversion was generally found, with a few exceptions, in the presence of an activating electron-donating substituent OH. The bioreduction aptitude of the NCYs was apparently correlated to the logP value: Compounds characterized by a higher logP exhibited a superior aptitude to be reduced by the NCYs than compounds with a lower logP value.

Non-conventional yeasts as sources of ene-reductases for the bioreduction of chalcones / Filippucci, S.; Tasselli, G.; Kenza Labbani, F. -Z.; Turchetti, B.; Rita Cramarossa, M.; Buzzini, P.; Forti, L.. - In: FERMENTATION. - ISSN 2311-5637. - 6:1(2020), pp. 1-10. [10.3390/fermentation6010029]

Non-conventional yeasts as sources of ene-reductases for the bioreduction of chalcones

Buzzini P.;Forti L.
2020

Abstract

Thirteen Non-Conventional Yeasts (NCYs) have been investigated for their ability to reduce activated C=C bonds of chalcones to obtain the corresponding dihydrochalcones. A possible correlation between bioreducing capacity of the NCYs and the substrate structure was estimated. Generally, whole-cells of the NCYs were able to hydrogenate the C=C double bond occurring in (E)-1,3-diphenylprop-2-en-1-one, while worthy bioconversion yields were obtained when the substrate exhibited the presence of a deactivating electron-withdrawing Cl substituent on the B-ring. On the contrary, no conversion was generally found, with a few exceptions, in the presence of an activating electron-donating substituent OH. The bioreduction aptitude of the NCYs was apparently correlated to the logP value: Compounds characterized by a higher logP exhibited a superior aptitude to be reduced by the NCYs than compounds with a lower logP value.
2020
6
1
1
10
Non-conventional yeasts as sources of ene-reductases for the bioreduction of chalcones / Filippucci, S.; Tasselli, G.; Kenza Labbani, F. -Z.; Turchetti, B.; Rita Cramarossa, M.; Buzzini, P.; Forti, L.. - In: FERMENTATION. - ISSN 2311-5637. - 6:1(2020), pp. 1-10. [10.3390/fermentation6010029]
Filippucci, S.; Tasselli, G.; Kenza Labbani, F. -Z.; Turchetti, B.; Rita Cramarossa, M.; Buzzini, P.; Forti, L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1207395
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