To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated alpha-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated alpha-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.

Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients / Antelmi, Elena; Pizza, Fabio; Donadio, Vincenzo; Filardi, Marco; Sosero, YURI LUDWIG; Incensi, Alex; Vandi, Stefano; Moresco, Monica; Ferri, Raffaele; Marelli, Sara; Ferini-Strambi, Luigi; Liguori, Rocco; Plazzi, Giuseppe. - In: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. - ISSN 2328-9503. - 6:9(2019), pp. 1872-1876. [10.1002/acn3.50833]

Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients

Moresco, Monica;Plazzi, Giuseppe
2019

Abstract

To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated alpha-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated alpha-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.
2019
6-ago-2019
6
9
1872
1876
Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients / Antelmi, Elena; Pizza, Fabio; Donadio, Vincenzo; Filardi, Marco; Sosero, YURI LUDWIG; Incensi, Alex; Vandi, Stefano; Moresco, Monica; Ferri, Raffaele; Marelli, Sara; Ferini-Strambi, Luigi; Liguori, Rocco; Plazzi, Giuseppe. - In: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. - ISSN 2328-9503. - 6:9(2019), pp. 1872-1876. [10.1002/acn3.50833]
Antelmi, Elena; Pizza, Fabio; Donadio, Vincenzo; Filardi, Marco; Sosero, YURI LUDWIG; Incensi, Alex; Vandi, Stefano; Moresco, Monica; Ferri, Raffaele;...espandi
File in questo prodotto:
File Dimensione Formato  
acn3.50833.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 99.49 kB
Formato Adobe PDF
99.49 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1206111
Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 40
  • ???jsp.display-item.citation.isi??? 39
social impact