Abstract: Electrophysiological investigations of restless legs syndrome (RLS) have found spinal circuits impinging on motoneurones. We evaluated the H reflex threshold, latency, the Hmax/Mmax ratio, and the short latency autogenic inhibition in 7 patients with RLS and 10 age-matched controls by testing the excitability changes in soleus H reflex Ib interneuron function. A significant reduction in Ib inhibition at 4 (P 0.043), 5 (P 0.007), and 6 ms (P 0.001) of H reflex conditioning interstimulus interval was found in RLS patients. Data support the hypothesis that altered group I nonreciprocal inhibition is implicated in enhancing the spinal circuitry excitability of RLS, and are consistent with the view of an abnormal supraspinal drive to spinal interneurons in RLS. © 2007 Movement Disorder Society

Group I nonreciprocal inhibition in primary restless legs sindrome / Scaglione, C.; Vetrugno, R.; Plazzi, G.; Rizzo, G.; Provini, F.; Montagna, P.; Martinelli, P.. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - 23:1(2008), pp. 96-100. [10.1002/mds.21794]

Group I nonreciprocal inhibition in primary restless legs sindrome

Plazzi G.;
2008

Abstract

Abstract: Electrophysiological investigations of restless legs syndrome (RLS) have found spinal circuits impinging on motoneurones. We evaluated the H reflex threshold, latency, the Hmax/Mmax ratio, and the short latency autogenic inhibition in 7 patients with RLS and 10 age-matched controls by testing the excitability changes in soleus H reflex Ib interneuron function. A significant reduction in Ib inhibition at 4 (P 0.043), 5 (P 0.007), and 6 ms (P 0.001) of H reflex conditioning interstimulus interval was found in RLS patients. Data support the hypothesis that altered group I nonreciprocal inhibition is implicated in enhancing the spinal circuitry excitability of RLS, and are consistent with the view of an abnormal supraspinal drive to spinal interneurons in RLS. © 2007 Movement Disorder Society
2008
23
1
96
100
Group I nonreciprocal inhibition in primary restless legs sindrome / Scaglione, C.; Vetrugno, R.; Plazzi, G.; Rizzo, G.; Provini, F.; Montagna, P.; Martinelli, P.. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - 23:1(2008), pp. 96-100. [10.1002/mds.21794]
Scaglione, C.; Vetrugno, R.; Plazzi, G.; Rizzo, G.; Provini, F.; Montagna, P.; Martinelli, P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1206107
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