BACKGROUND AND PURPOSE: The aim of this study was to evaluate the presence of abnormalities in the brain of patients with restless legs syndrome (RLS) using voxel-based morphometry and diffusion tensor imaging (DTI). METHODS: Twenty patients and twenty controls were studied. Voxel-based morphometry analysis was performed using statistical parametric mapping (SPM8) and FSL-VBM software tools. For voxel-wise analysis of DTI, tract-based spatial statistics (TBSS) and SPM8 were used. RESULTS: Applying an appropriate threshold of probability, no significant results were found either in comparison or in correlation analyses. CONCLUSIONS: Our data argue against clear structural or microstructural abnormalities in the brain of patients with idiopathic RLS, suggesting a prevalent role of functional or metabolic impairment.

Combined brain voxel-based morphometry and diffusion tensor imaging study in idiopathic Restless Legs Syndrome patients / Rizzo, G.; Manners, D.; Vetrugno, R.; Tonon, C.; Malucelli, E.; Plazzi, G.; Marconi, S.; Pizza, F.; Testa, C.; Provini, F.; Montagna, P.; Lodi, R.. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - 19:7(2012), pp. 1045-1049. [10.1111/j.1468-1331.2011.03604.x]

Combined brain voxel-based morphometry and diffusion tensor imaging study in idiopathic Restless Legs Syndrome patients

Plazzi G.;
2012

Abstract

BACKGROUND AND PURPOSE: The aim of this study was to evaluate the presence of abnormalities in the brain of patients with restless legs syndrome (RLS) using voxel-based morphometry and diffusion tensor imaging (DTI). METHODS: Twenty patients and twenty controls were studied. Voxel-based morphometry analysis was performed using statistical parametric mapping (SPM8) and FSL-VBM software tools. For voxel-wise analysis of DTI, tract-based spatial statistics (TBSS) and SPM8 were used. RESULTS: Applying an appropriate threshold of probability, no significant results were found either in comparison or in correlation analyses. CONCLUSIONS: Our data argue against clear structural or microstructural abnormalities in the brain of patients with idiopathic RLS, suggesting a prevalent role of functional or metabolic impairment.
2012
19
7
1045
1049
Combined brain voxel-based morphometry and diffusion tensor imaging study in idiopathic Restless Legs Syndrome patients / Rizzo, G.; Manners, D.; Vetrugno, R.; Tonon, C.; Malucelli, E.; Plazzi, G.; Marconi, S.; Pizza, F.; Testa, C.; Provini, F.; Montagna, P.; Lodi, R.. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - 19:7(2012), pp. 1045-1049. [10.1111/j.1468-1331.2011.03604.x]
Rizzo, G.; Manners, D.; Vetrugno, R.; Tonon, C.; Malucelli, E.; Plazzi, G.; Marconi, S.; Pizza, F.; Testa, C.; Provini, F.; Montagna, P.; Lodi, R....espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1206104
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