The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.
The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder / Gan-Or, Ziv; Montplaisir Jacques, Y; Ross Jay, P; Poirier, Judes; Warby Simon, C; Arnulf, Isabelle; Strong, Stephanie; Dauvilliers, Yves; Leblond Claire, S; Hu Michele, T M; Högl, Birgit; Stefani, Ambra; Monaca Christelle, Charley; De Cock Valérie, Cochen; Boivin, Michel; Ferini-Strambi, Luigi; Plazzi, Giuseppe; Antelmi, Elena; Young, Peter; Heidbreder, Anna; Barber Thomas, R; Evetts Samuel, G; Rolinski, Michal; Dion Patrick, A; Desautels, Alex; Gagnon, Jean-François; Dupré, Nicolas; Postuma Ronald, B; Rouleau Guy, A. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - 49:(2017), pp. 218.e13-218.e15. [10.1016/j.neurobiolaging.2016.10.002]
The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder
Plazzi Giuseppe;
2017
Abstract
The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.
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