OBJECTIVE: To evaluate the 5-year variation of health-related quality of life (HRQoL) and mood symptoms in a cohort of patients with narcolepsy. METHODS: Adults attending the Sleep Centre of the Department of Neurological Sciences, University of Bologna in 1997 and meeting the International Classification of Sleep Disorders-Revised criteria for the diagnosis of narcolepsy were eligible. Included patients self-administered the Medical Outcome Short Form-36 (SF-36) and the Zung depression scale (ZDS) prospectively in 1998 and 2003. RESULTS: There was no significant difference between 1998 and 2003 measures of SF-36 and ZDS in the 54 patients included. About 25% of them showed moderate or severe mood symptoms in both observations. ZDS score (inversely) and duration of disease (directly) explained a percentage of variance of role physical, vitality (VT), social functioning (SF) and role emotional. At the second observation VT and SF had a further percentage of variance explained by excessive daytime sleepiness (EDS) and age at onset. Self-reported diabetes frequency doubled after 5 years (from 7% to 17%). CONCLUSIONS: Patients with narcolepsy show a stable impairment of HRQoL in a 5-year period with respect to Italian normative data. Mood status and EDS negatively influence their HRQoL while disease duration has a positive influence.

A 5-year prospective cohort study on health-related quality of life in patients with narcolepsy / Vignatelli, L.; Plazzi, Giuseppe; Peschechera, F.; Delaj, L.; D'Alessandro, Roberto. - In: SLEEP MEDICINE. - ISSN 1389-9457. - 12:1(2011), pp. 19-23. [10.1016/j.sleep.2010.07.008]

A 5-year prospective cohort study on health-related quality of life in patients with narcolepsy

PLAZZI, GIUSEPPE;
2011

Abstract

OBJECTIVE: To evaluate the 5-year variation of health-related quality of life (HRQoL) and mood symptoms in a cohort of patients with narcolepsy. METHODS: Adults attending the Sleep Centre of the Department of Neurological Sciences, University of Bologna in 1997 and meeting the International Classification of Sleep Disorders-Revised criteria for the diagnosis of narcolepsy were eligible. Included patients self-administered the Medical Outcome Short Form-36 (SF-36) and the Zung depression scale (ZDS) prospectively in 1998 and 2003. RESULTS: There was no significant difference between 1998 and 2003 measures of SF-36 and ZDS in the 54 patients included. About 25% of them showed moderate or severe mood symptoms in both observations. ZDS score (inversely) and duration of disease (directly) explained a percentage of variance of role physical, vitality (VT), social functioning (SF) and role emotional. At the second observation VT and SF had a further percentage of variance explained by excessive daytime sleepiness (EDS) and age at onset. Self-reported diabetes frequency doubled after 5 years (from 7% to 17%). CONCLUSIONS: Patients with narcolepsy show a stable impairment of HRQoL in a 5-year period with respect to Italian normative data. Mood status and EDS negatively influence their HRQoL while disease duration has a positive influence.
2011
12
1
19
23
A 5-year prospective cohort study on health-related quality of life in patients with narcolepsy / Vignatelli, L.; Plazzi, Giuseppe; Peschechera, F.; Delaj, L.; D'Alessandro, Roberto. - In: SLEEP MEDICINE. - ISSN 1389-9457. - 12:1(2011), pp. 19-23. [10.1016/j.sleep.2010.07.008]
Vignatelli, L.; Plazzi, Giuseppe; Peschechera, F.; Delaj, L.; D'Alessandro, Roberto
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1206009
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