Rapid-eye-movement (REM) sleep without atonia (RSWA) is a marker of REM sleep behavior disorder (RBD) and is common in narcolepsy. Available techniques for electromyogram (EMG) analysis are species-specific, limiting translational research on RSWA. We developed an automated technique based on distributions of normalized EMG values (DNE) to overcome this limitation. With DNE, we tested whether the control of neck and tibialis anterior (TA) muscles during sleep in wild-type rats and mice validly models the control of submentalis (chin) and TA muscles in healthy humans. We then applied DNE to REM sleep recordings of patients with idiopathic RBD and of mouse models of narcolepsy, testing for a common DNE signature of RSWA.

Muscle Activity During Sleep in Human Subjects, Rats, and Mice: Towards Translational Models of REM Sleep Without Atonia / Silvani, Alessandro; Ferri, Raffaele; Lo Martire, Viviana Carmen; Bastianini, Stefano; Berteotti, Chiara; Salvadè, Agnese; Plazzi, Giuseppe; Zucconi, Marco; Ferini Strambi, Luigi; Bassetti, Claudio L; Manconi, Mauro; Zoccoli, Giovanna. - In: SLEEP. - ISSN 0161-8105. - 40:4(2017), pp. 1-10.

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