Study Objectives: To evaluate the effect of type 1 narcolepsy (NT1) on anthropometric and endocrine features in childhood/adolescence, focusing on patterns and correlates of weight, pubertal development, and growth in treated and untreated patients. Methods: We collected anthropometric (height, weight, body mass index (BMI) z-scores), pubertal, metabolic, and endocrine data from 72 NT1 patients at diagnosis and all available premorbid anthropometric parameters of patients from their pediatric files (n = 30). New measurements at 1-y reassessment in patients undergoing different treatments were compared with baseline data. Results: We detected a high prevalence of overweight (29.2%), obesity (25%), metabolic syndrome (18.8%), and precocious puberty (16.1%), but no signs of linear growth alterations at diagnosis. According to anthropometric records, weight gain started soon after NT1 onset. At 1-y follow-up reassessment, sodium oxybate treatment was associated with a significant BMI z-score reduction (-1.29 ± 0.30, p < 0.0005) after adjusting for baseline age, sex, sleepiness, and BMI. Conclusions: NT1 onset in children/adolescents is associated with rapid weight gain up to overweight/obesity and precocious puberty without affecting growth. In our study, sodium oxybate treatment resulted in a significant weight reduction in NT1 overweight/obese patients at 1-y follow-up.
Growing Up with Type 1 narcolepsy: Its anthropometric and endocrine features / Ponziani, Virginia; Gennari, Monia; Pizza, Fabio; Balsamo, Antonio; Bernardi, Filippo; Plazzi, Giuseppe. - In: JOURNAL OF CLINICAL SLEEP MEDICINE. - ISSN 1550-9389. - 12:12(2016), pp. 1649-1657.
Data di pubblicazione: | 2016 |
Titolo: | Growing Up with Type 1 narcolepsy: Its anthropometric and endocrine features |
Autore/i: | Ponziani, Virginia; Gennari, Monia; Pizza, Fabio; Balsamo, Antonio; Bernardi, Filippo; Plazzi, Giuseppe |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.5664/jcsm.6352 |
Rivista: | |
Volume: | 12 |
Fascicolo: | 12 |
Pagina iniziale: | 1649 |
Pagina finale: | 1657 |
Codice identificativo ISI: | WOS:000389998300011 |
Codice identificativo Scopus: | 2-s2.0-85006386950 |
Codice identificativo Pubmed: | 27707443 |
Citazione: | Growing Up with Type 1 narcolepsy: Its anthropometric and endocrine features / Ponziani, Virginia; Gennari, Monia; Pizza, Fabio; Balsamo, Antonio; Bernardi, Filippo; Plazzi, Giuseppe. - In: JOURNAL OF CLINICAL SLEEP MEDICINE. - ISSN 1550-9389. - 12:12(2016), pp. 1649-1657. |
Tipologia | Articolo su rivista |
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