EnglishCentral nervous system (CNS) compartments remain one of the most difficult districts for drug delivery. This is due to the presence of the blood–brain barrier (BBB) that hampers 90% of drug passage, dramatically requiring non-invasive treatment strategies. Here, for the first time, the use of opioid-derived deltorphin-derivative peptides to drive biodegradable and biocompatible polymeric (i.e. poly-lactide-co-glycolide, PLGA) nanomedicines delivery across the BBB was described. Opioid-derived peptides were covalently conjugated to furnish activated polymers which were further used for fluorescently tagged nanoformulations. Beyond reporting production, formulation methodology and full physico-chemical characterization, in vivo tests generated clear proof of BBB crossing and CNS targeting by engineered nanomedicines opening the research to further applications of drug delivery and targeting in CNS disease models.
Novel peptide-conjugated nanomedicines for brain targeting: In vivo evidence / Duskey, J. T.; Ottonelli, I.; Da Ros, F.; Vilella, A.; Zoli, M.; Kovachka, S.; Spyrakis, F.; Vandelli, M. A.; Tosi, G.; Ruozi, B.. - In: NANOMEDICINE. - ISSN 1549-9634. - 28(2020), pp. 102226-102226.
| Data di pubblicazione: | 2020 |
| Data di prima pubblicazione: | 29-mag-2020 |
| Titolo: | Novel peptide-conjugated nanomedicines for brain targeting: In vivo evidence |
| Autore/i: | Duskey, J. T.; Ottonelli, I.; Da Ros, F.; Vilella, A.; Zoli, M.; Kovachka, S.; Spyrakis, F.; Vandelli, M. A.; Tosi, G.; Ruozi, B. |
| Autore/i UNIMORE: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.nano.2020.102226 |
| Rivista: | |
| Volume: | 28 |
| Pagina iniziale: | 102226 |
| Pagina finale: | 102226 |
| Codice identificativo ISI: | WOS:000563777100004 |
| Codice identificativo Scopus: | 2-s2.0-85087279065 |
| Codice identificativo Pubmed: | 32479916 |
| Citazione: | Novel peptide-conjugated nanomedicines for brain targeting: In vivo evidence / Duskey, J. T.; Ottonelli, I.; Da Ros, F.; Vilella, A.; Zoli, M.; Kovachka, S.; Spyrakis, F.; Vandelli, M. A.; Tosi, G.; Ruozi, B.. - In: NANOMEDICINE. - ISSN 1549-9634. - 28(2020), pp. 102226-102226. |
| Tipologia | Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | |
|---|---|---|---|
| 1-s2.0-S1549963420300800-main (1).pdf | Articolo principale | Versione dell'editore (versione pubblicata) | Administrator Richiedi una copia |
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
Copyright © 2021