An open clinical investigation on clinical dermatoscopy, OCT and RCM visible effects of application of a new topical product for 6 months on brittle nails and weak nails with rough surface and/or tendency to break

Introduction & Objectives Nail brittleness is a common complaint characterized by weak nails with rough surface and/or tendency to split, flake and crumble. This nail alteration can be a consequence of factors that alter the nail plate production or factors that damage the nail plate, such as cosmetics (permanent and non-permanent nail lacquers), psoriasis, lichen planus, ageing, chemotherapy, other drugs and anaemia. The aim of our study was to evaluate the effectiveness, tolerability and patient’s compliance of a new water-soluble nail lacquer with silicon and keratin synthesis booster product for brittle and weak nails. Material & Methods 30 patients of both sexes, aged >18 years, affected by nail brittleness were prescribed a new topical therapy to be applied on the affected nails once a day for 6 months. The new product is dispensed by a pencil unit with a brush and has to be applied on the entire edge of the nail, cuticle included. Periodic evaluation of treatment efficacy was performed by standardized photography and dry video-dermoscopy of the target nail at baseline (V1), after 15 days (V2), 1 month (V3), 3 months (V4) and 6 months (V5). The treatment efficacy was evaluated by the experimentator through Global and Trichoscopy Assessment Scale and by patients through a patient global assessment and a specify questionnaire. 10 patients also underwent to Optical Coherence Tomography (OCT) in order to have a further objective parameter of efficacy evaluation. Results All patients concluded the study, with marked improvement of nail weakness and appearance. No side effects were recorded. All patients judged the treatment easy to apply and effective. Conclusions This new water-soluble nail lacquer with silicon and keratin synthesis booster is an effective and safe option for the treatment of nail brittleness and damages.