The T Cell Project was the largest prospective trial to explore the incidence, treatment patterns, and outcomes for T cell lymphomas. The rare subtypes of T cell lymphomas, including hepatosplenic T cell lymphoma (HSTCL), enteropathy associated T cell lymphoma (EATL), and peripheral gamma delta T cell lymphomas (PGDTCLs) are poorly represented in most studies and there is little data regarding treatment patterns. We report results from 115 patients with hepatosplenic (n = 31), enteropathy associated (n = 65), and PGDTCLs (n = 19). While anthracycline regimens were most commonly used as first line therapy, response rates ranged from 20%-40% and were suboptimal for all groups. Autologous stem cell transplantation was performed as a consolidation in first remission in a small number of patients (33% of HSTCL, 7% of EATL, and 12% of PGDTCL), and four patients with HSTCL underwent allogeneic stem cell transplantation in first remission. The progression free survival at 3 years ranged from 28%-40% for these rare subtypes, and the overall survival at 3 years was most favorable for PGDTCL (70%). These data highlight the need for novel treatment approaches for rare subtypes of T cell lymphomas and for their inclusion in clinical trials.

Incidence and outcomes of rare T cell lymphomas from the T Cell Project: hepatosplenic, enteropathy associated and peripheral gamma delta T cell lymphomas / Foss, Francine M; Horwitz, Steven M; Civallero, Monica; Bellei, Monica; Marcheselli, Luigi; Kim, Won Seog; Cabrera, Maria E; Dlouhy, Ivan; Nagler, Arnon; Advani, Ranjana H; Pesce, Emanuela A; Ko, Young-Hyeh; Montoto, Silvia; Chiattone, Carlos; Moskowitz, Alison; Spina, Michele; Cesaretti, Marina; Biasoli, Irene; Federico, Massimo. - In: AMERICAN JOURNAL OF HEMATOLOGY. - ISSN 0361-8609. - 95:2(2020), pp. 151-155. [10.1002/ajh.25674]

Incidence and outcomes of rare T cell lymphomas from the T Cell Project: hepatosplenic, enteropathy associated and peripheral gamma delta T cell lymphomas

Civallero, Monica;Bellei, Monica;Marcheselli, Luigi;Pesce, Emanuela A;Cesaretti, Marina;Federico, Massimo
2020

Abstract

The T Cell Project was the largest prospective trial to explore the incidence, treatment patterns, and outcomes for T cell lymphomas. The rare subtypes of T cell lymphomas, including hepatosplenic T cell lymphoma (HSTCL), enteropathy associated T cell lymphoma (EATL), and peripheral gamma delta T cell lymphomas (PGDTCLs) are poorly represented in most studies and there is little data regarding treatment patterns. We report results from 115 patients with hepatosplenic (n = 31), enteropathy associated (n = 65), and PGDTCLs (n = 19). While anthracycline regimens were most commonly used as first line therapy, response rates ranged from 20%-40% and were suboptimal for all groups. Autologous stem cell transplantation was performed as a consolidation in first remission in a small number of patients (33% of HSTCL, 7% of EATL, and 12% of PGDTCL), and four patients with HSTCL underwent allogeneic stem cell transplantation in first remission. The progression free survival at 3 years ranged from 28%-40% for these rare subtypes, and the overall survival at 3 years was most favorable for PGDTCL (70%). These data highlight the need for novel treatment approaches for rare subtypes of T cell lymphomas and for their inclusion in clinical trials.
25-nov-2019
95
2
151
155
Incidence and outcomes of rare T cell lymphomas from the T Cell Project: hepatosplenic, enteropathy associated and peripheral gamma delta T cell lymphomas / Foss, Francine M; Horwitz, Steven M; Civallero, Monica; Bellei, Monica; Marcheselli, Luigi; Kim, Won Seog; Cabrera, Maria E; Dlouhy, Ivan; Nagler, Arnon; Advani, Ranjana H; Pesce, Emanuela A; Ko, Young-Hyeh; Montoto, Silvia; Chiattone, Carlos; Moskowitz, Alison; Spina, Michele; Cesaretti, Marina; Biasoli, Irene; Federico, Massimo. - In: AMERICAN JOURNAL OF HEMATOLOGY. - ISSN 0361-8609. - 95:2(2020), pp. 151-155. [10.1002/ajh.25674]
Foss, Francine M; Horwitz, Steven M; Civallero, Monica; Bellei, Monica; Marcheselli, Luigi; Kim, Won Seog; Cabrera, Maria E; Dlouhy, Ivan; Nagler, Arnon; Advani, Ranjana H; Pesce, Emanuela A; Ko, Young-Hyeh; Montoto, Silvia; Chiattone, Carlos; Moskowitz, Alison; Spina, Michele; Cesaretti, Marina; Biasoli, Irene; Federico, Massimo
File in questo prodotto:
File Dimensione Formato  
466.pdf

non disponibili

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 1.93 MB
Formato Adobe PDF
1.93 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1205047
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 20
social impact