Polyvinylchloride is universally agreed upon to be the material of choice for tubings and for containers for medical application. Many alterations of the chemical/physical surface conditions, mainly due to an altered extrusion process, could influence its biocompatibility by promoting platelet aggregation. Biocompatibility and safety of the medical device must be preserved, also monitoring the migration of additives within polyvinylchloride during the diffusion process. A large variety of methods are used to verify the correct composition and extrusion of polyvinylchloride but, generally, they need long experimental time and are expensive. The aim of the study is to propose a simple, economic and rapid approach based on Fourier transform-infrared spectroscopy and Coomassie Blue staining. The method has been used to detect chemical and morphological defects caused by an altered extrusion process on 20/75 polyvinylchloride tubings in a blind test. This approach positively identified altered samples in 80% of the cases. The suggested approach represents a reliable and versatile method to detect and monitor surface defects by an easy, inexpensive and reproducible method.

Microscopic and chemical characterization of PVC tube used for dialysis lines: A new approach / Petrachi, T.; Arnaud, G. F.; Roncioni, S.; Resca, E.; Veronesi, E.; Dominici, M.; Tomasi, A.; Cuoghi, A.. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - (2020), pp. 039139882093217-039139882093218. [10.1177/0391398820932178]

Microscopic and chemical characterization of PVC tube used for dialysis lines: A new approach

Petrachi T.;Arnaud G. F.;Resca E.;Veronesi E.;Dominici M.;Tomasi A.;Cuoghi A.
2020

Abstract

Polyvinylchloride is universally agreed upon to be the material of choice for tubings and for containers for medical application. Many alterations of the chemical/physical surface conditions, mainly due to an altered extrusion process, could influence its biocompatibility by promoting platelet aggregation. Biocompatibility and safety of the medical device must be preserved, also monitoring the migration of additives within polyvinylchloride during the diffusion process. A large variety of methods are used to verify the correct composition and extrusion of polyvinylchloride but, generally, they need long experimental time and are expensive. The aim of the study is to propose a simple, economic and rapid approach based on Fourier transform-infrared spectroscopy and Coomassie Blue staining. The method has been used to detect chemical and morphological defects caused by an altered extrusion process on 20/75 polyvinylchloride tubings in a blind test. This approach positively identified altered samples in 80% of the cases. The suggested approach represents a reliable and versatile method to detect and monitor surface defects by an easy, inexpensive and reproducible method.
039139882093217
039139882093218
Microscopic and chemical characterization of PVC tube used for dialysis lines: A new approach / Petrachi, T.; Arnaud, G. F.; Roncioni, S.; Resca, E.; Veronesi, E.; Dominici, M.; Tomasi, A.; Cuoghi, A.. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - (2020), pp. 039139882093217-039139882093218. [10.1177/0391398820932178]
Petrachi, T.; Arnaud, G. F.; Roncioni, S.; Resca, E.; Veronesi, E.; Dominici, M.; Tomasi, A.; Cuoghi, A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1204849
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