EnglishSummary: Here we present APTANI2, an expanded and optimized version of APTANI, a computational tool for selecting target-specific aptamers from high-throughput-Systematic Evolution of Ligands by Exponential Enrichment data through sequence-structure analysis. As compared to its original implementation, APTANI2 ranks aptamers and identifies relevant structural motifs through the calculation of a score that combines frequency and structural stability of each secondary structure predicted in any aptamer sequence. In addition, APTANI2 comprises modules for a deeper investigation of sequence motifs and secondary structures, a graphical user interface that enhances its usability, and coding solutions that improve performances.
APTANI2: Update of aptamer selection through sequence-structure analysis / Caroli, J.; Forcato, M.; Bicciato, S.. - In: BIOINFORMATICS. - ISSN 1367-4803. - 36:7(2020), pp. 2266-2268.
| Data di pubblicazione: | 2020 |
| Titolo: | APTANI2: Update of aptamer selection through sequence-structure analysis |
| Autore/i: | Caroli, J.; Forcato, M.; Bicciato, S. |
| Autore/i UNIMORE: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1093/bioinformatics/btz897 |
| Rivista: | |
| Volume: | 36 |
| Fascicolo: | 7 |
| Pagina iniziale: | 2266 |
| Pagina finale: | 2268 |
| Codice identificativo ISI: | WOS:000536489400044 |
| Codice identificativo Scopus: | 2-s2.0-85083079633 |
| Codice identificativo Pubmed: | 31778141 |
| Citazione: | APTANI2: Update of aptamer selection through sequence-structure analysis / Caroli, J.; Forcato, M.; Bicciato, S.. - In: BIOINFORMATICS. - ISSN 1367-4803. - 36:7(2020), pp. 2266-2268. |
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