The pathophysiological mechanism of medication overuse headache is uncertain; no distinctive markers have been described right now. The aim of this study was to conduct proteomic analyses on serum samples from patients with medication overuse headache and healthy individuals. Specifically, mono- (SDS-PAGE) and two-dimensional gel electrophoresis (2-DE) followed by liquid chromatography tandem mass spectrometry (LC-MS/MS) were used to evaluate changes in serum proteins.
Identification of candidate proteomic markers in the serum of medication overuse headache patients: An exploratory study / Pellesi, Lanfranco; Guerzoni, Simona; Baraldi, Carlo; Cainazzo, Maria Michela; Pini, Luigi Alberto; Bellei, Elisa. - In: CEPHALALGIA. - ISSN 0333-1024. - 40:10(2020), pp. 1070-1078. [10.1177/0333102420921847]
Identification of candidate proteomic markers in the serum of medication overuse headache patients: An exploratory study
Baraldi, Carlo;Pini, Luigi Alberto;Bellei, Elisa
2020
Abstract
The pathophysiological mechanism of medication overuse headache is uncertain; no distinctive markers have been described right now. The aim of this study was to conduct proteomic analyses on serum samples from patients with medication overuse headache and healthy individuals. Specifically, mono- (SDS-PAGE) and two-dimensional gel electrophoresis (2-DE) followed by liquid chromatography tandem mass spectrometry (LC-MS/MS) were used to evaluate changes in serum proteins.
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