Introduction: This Experts’ opinion provides an updated scientific support to gynecologists, obstetricians, endocrinologists, nutritionists, neurologists and general practitioners on the use of Inositols in the therapy of Polycystic Ovary Syndrome (PCOS) and non-insulin dependent (type 2) diabetes mellitus (NIDDM). Areas covered: This paper summarizes the physiology of Myo-Inositol (MI) and D-Chiro-Inositol (DCI), two important molecules present in human organisms, and their therapeutic role, also for treating infertility. Some deep differences between the physiological functions of MI and DCI, as well as their safety and intestinal absorption are discussed. Updates include new evidence on the efficacy exerted in PCOS by the 40:1 MI/DCI ratio, and the innovative approach based on alpha-lactalbumin to overcome the decreased therapeutic efficacy of Inositols in some patients. Expert opinion: The evidence suggests that MI, alone or with DCI in the 40:1 ratio, offers a promising treatment for PCOS and NIDDM. However, additional studies need to evaluate some still unresolved issues, such as the best MI/DCI ratio for treating NIDDM, the potential cost-effectiveness of reduced gonadotropins administration in IVF due to MI treatment, or the benefit of MI supplementation in ovulation induction with clomiphene citrate in PCOS patients.

Experts’ opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond / Facchinetti, F.; Appetecchia, M.; Aragona, C.; Bevilacqua, A.; Bezerra Espinola, M. S.; Bizzarri, M.; D'Anna, R.; Dewailly, D.; Diamanti-Kandarakis, E.; Hernandez Marin, I.; Kamenov, Z. A.; Kandaraki, E.; Lagana, A. S.; Monastra, G.; Montanino Oliva, M.; Nestler, J. E.; Orio, F.; Ozay, A. C.; Papalou, O.; Pkhaladze, L.; Porcaro, G.; Prapas, N.; Soulage, C. O.; Stringaro, A.; Wdowiak, A.; Unfer, V.. - In: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. - ISSN 1742-5255. - 16:3(2020), pp. 255-274. [10.1080/17425255.2020.1737675]

Experts’ opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond

Facchinetti F.;D'Anna R.;
2020

Abstract

Introduction: This Experts’ opinion provides an updated scientific support to gynecologists, obstetricians, endocrinologists, nutritionists, neurologists and general practitioners on the use of Inositols in the therapy of Polycystic Ovary Syndrome (PCOS) and non-insulin dependent (type 2) diabetes mellitus (NIDDM). Areas covered: This paper summarizes the physiology of Myo-Inositol (MI) and D-Chiro-Inositol (DCI), two important molecules present in human organisms, and their therapeutic role, also for treating infertility. Some deep differences between the physiological functions of MI and DCI, as well as their safety and intestinal absorption are discussed. Updates include new evidence on the efficacy exerted in PCOS by the 40:1 MI/DCI ratio, and the innovative approach based on alpha-lactalbumin to overcome the decreased therapeutic efficacy of Inositols in some patients. Expert opinion: The evidence suggests that MI, alone or with DCI in the 40:1 ratio, offers a promising treatment for PCOS and NIDDM. However, additional studies need to evaluate some still unresolved issues, such as the best MI/DCI ratio for treating NIDDM, the potential cost-effectiveness of reduced gonadotropins administration in IVF due to MI treatment, or the benefit of MI supplementation in ovulation induction with clomiphene citrate in PCOS patients.
2020
19-mar-2020
16
3
255
274
Experts’ opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond / Facchinetti, F.; Appetecchia, M.; Aragona, C.; Bevilacqua, A.; Bezerra Espinola, M. S.; Bizzarri, M.; D'Anna, R.; Dewailly, D.; Diamanti-Kandarakis, E.; Hernandez Marin, I.; Kamenov, Z. A.; Kandaraki, E.; Lagana, A. S.; Monastra, G.; Montanino Oliva, M.; Nestler, J. E.; Orio, F.; Ozay, A. C.; Papalou, O.; Pkhaladze, L.; Porcaro, G.; Prapas, N.; Soulage, C. O.; Stringaro, A.; Wdowiak, A.; Unfer, V.. - In: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. - ISSN 1742-5255. - 16:3(2020), pp. 255-274. [10.1080/17425255.2020.1737675]
Facchinetti, F.; Appetecchia, M.; Aragona, C.; Bevilacqua, A.; Bezerra Espinola, M. S.; Bizzarri, M.; D'Anna, R.; Dewailly, D.; Diamanti-Kandarakis, E.; Hernandez Marin, I.; Kamenov, Z. A.; Kandaraki, E.; Lagana, A. S.; Monastra, G.; Montanino Oliva, M.; Nestler, J. E.; Orio, F.; Ozay, A. C.; Papalou, O.; Pkhaladze, L.; Porcaro, G.; Prapas, N.; Soulage, C. O.; Stringaro, A.; Wdowiak, A.; Unfer, V.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1201689
Citazioni
  • ???jsp.display-item.citation.pmc??? 25
  • Scopus 50
  • ???jsp.display-item.citation.isi??? 39
social impact