BACKGROUND: To investigate anatomical/functional changes after oral eplerenone therapy for chronic central serous chorioretinopathy (CCSC) in successfully treated eyes and fellow eyes and assess timing of foveal subretinal fluid (SRF) resolution. METHODS: Twenty-one eyes of 21 patients suffering from CCSC with monolateral foveal SRF successfully treated with oral eplerenone were enrolled in this retrospective study (group 1). The fellow eyes (21 eyes; group 2), healthy or affected by CCSC, without foveal SRF were considered in the analysis. A control healthy group was enrolled as well (healthy controls; n = 21). Main outcome measures during follow-up included changes of best corrected visual acuity (BCVA, logMAR), central macular thickness (CMT; µm), SRF (µm), subfoveal choroidal thickness (SFCT; µm), superficial capillary plexus density (SCPD, %), deep capillary plexus density (DCPD, %), and choriocapillaris density (CCD, %) and percentage of eyes showing foveal SRF resolution at different time points. RESULTS: Functional and anatomical parameters significantly improved during the study in group 1. BCVA increased significantly (p < 0.001), while CMT, SFCT, and SRF decreased significantly (p < 0.001; p < 0.001, and p = 0.037, respectively). SCPD, DCPD, and CCD did not show any statistically significant difference during follow-up. In 71.4% of eyes, resolution of SRF was observed within 60 days and in the remaining 28.6%, at 120 days. In fellow eyes, SFCT decreased significantly (p < 0.001), whilst all other parameters did not modify. CONCLUSIONS: Eplerenone treatment in chronic CSCR potentially improves recovery of retinal and choroidal morphology as well as visual acuity gain. A complete resolution of foveal SRF was observed in all eyes during a 4-month follow-up, with most eyes healing at 2 months. KEYWORDS: choriocapillaris density; chronic central serous chorioretinopathy; eplerenone therapy; optical coherence tomography angiography; subfoveal choroidal thickness; superficial capillary plexus density

Anatomical and Functional Changes of the Retina and the Choroid after Resolved Chronic CSCR / Toto, Lisa; D'Aloisio, Rossella; Mastropasqua, Rodolfo; Di Antonio, Luca; Di Nicola, Marta; Di Martino, Giuseppe; Evangelista, Federica; Erroi, Emanuele; Doronzo, Emanuele; Mariotti, Cesare. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 8:4(2019), pp. 474-485. [10.3390/jcm8040474]

Anatomical and Functional Changes of the Retina and the Choroid after Resolved Chronic CSCR

Mastropasqua, Rodolfo;
2019

Abstract

BACKGROUND: To investigate anatomical/functional changes after oral eplerenone therapy for chronic central serous chorioretinopathy (CCSC) in successfully treated eyes and fellow eyes and assess timing of foveal subretinal fluid (SRF) resolution. METHODS: Twenty-one eyes of 21 patients suffering from CCSC with monolateral foveal SRF successfully treated with oral eplerenone were enrolled in this retrospective study (group 1). The fellow eyes (21 eyes; group 2), healthy or affected by CCSC, without foveal SRF were considered in the analysis. A control healthy group was enrolled as well (healthy controls; n = 21). Main outcome measures during follow-up included changes of best corrected visual acuity (BCVA, logMAR), central macular thickness (CMT; µm), SRF (µm), subfoveal choroidal thickness (SFCT; µm), superficial capillary plexus density (SCPD, %), deep capillary plexus density (DCPD, %), and choriocapillaris density (CCD, %) and percentage of eyes showing foveal SRF resolution at different time points. RESULTS: Functional and anatomical parameters significantly improved during the study in group 1. BCVA increased significantly (p < 0.001), while CMT, SFCT, and SRF decreased significantly (p < 0.001; p < 0.001, and p = 0.037, respectively). SCPD, DCPD, and CCD did not show any statistically significant difference during follow-up. In 71.4% of eyes, resolution of SRF was observed within 60 days and in the remaining 28.6%, at 120 days. In fellow eyes, SFCT decreased significantly (p < 0.001), whilst all other parameters did not modify. CONCLUSIONS: Eplerenone treatment in chronic CSCR potentially improves recovery of retinal and choroidal morphology as well as visual acuity gain. A complete resolution of foveal SRF was observed in all eyes during a 4-month follow-up, with most eyes healing at 2 months. KEYWORDS: choriocapillaris density; chronic central serous chorioretinopathy; eplerenone therapy; optical coherence tomography angiography; subfoveal choroidal thickness; superficial capillary plexus density
2019
8
4
474
485
Anatomical and Functional Changes of the Retina and the Choroid after Resolved Chronic CSCR / Toto, Lisa; D'Aloisio, Rossella; Mastropasqua, Rodolfo; Di Antonio, Luca; Di Nicola, Marta; Di Martino, Giuseppe; Evangelista, Federica; Erroi, Emanuele; Doronzo, Emanuele; Mariotti, Cesare. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 8:4(2019), pp. 474-485. [10.3390/jcm8040474]
Toto, Lisa; D'Aloisio, Rossella; Mastropasqua, Rodolfo; Di Antonio, Luca; Di Nicola, Marta; Di Martino, Giuseppe; Evangelista, Federica; Erroi, Emanuele; Doronzo, Emanuele; Mariotti, Cesare
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1201130
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