Background: The impact of the Pringle maneuver (PM) on long-term outcome after curative resection for hepatocellular carcinoma (HCC) is controversial, with eastern series reporting conflicting results. We aim to evaluate the impact of the PM in a western cohort. Methods: We retrospectively analyzed patients with HCC who underwent liver resection between January 2001 and August 2015. Patients were divided in two groups based the use of the PM during resection. Primary outcomes were overall survival (OS) and disease-free survival (DFS). Results: A total of 441 patients were analyzed. Of these, 176 patients (39.9%) underwent PM. Median OS was 46.4 months (95%CI: 34.1-58.7) for the PM group and 56.5 months (95%CI: 37.1-75.9) for the no-PM group (P = 0.188), with a median DFS of 26.7 months (95%CI: 15.7-37.7) and 24.9 months (95%CI: 18.1-31.7), respectively (P = 0.883). Conclusions: These results suggest that PM does not increase the risk of tumor recurrence or decrease long-term survival.

Does the Pringle maneuver affect survival and recurrence following surgical resection for hepatocellular carcinoma? A western series of 441 patients / Famularo, S; Giani, A; Di Sandro, S; Sandini, M; Giacomoni, A; Pinotti, E; Lauterio, A; Gianotti, L; De Carlis, L; Romano, F. - In: JOURNAL OF SURGICAL ONCOLOGY. - ISSN 0022-4790. - 117:2(2018), pp. 198-206. [10.1002/jso.24819]

Does the Pringle maneuver affect survival and recurrence following surgical resection for hepatocellular carcinoma? A western series of 441 patients

Di Sandro S
Supervision
;
Pinotti E;
2018

Abstract

Background: The impact of the Pringle maneuver (PM) on long-term outcome after curative resection for hepatocellular carcinoma (HCC) is controversial, with eastern series reporting conflicting results. We aim to evaluate the impact of the PM in a western cohort. Methods: We retrospectively analyzed patients with HCC who underwent liver resection between January 2001 and August 2015. Patients were divided in two groups based the use of the PM during resection. Primary outcomes were overall survival (OS) and disease-free survival (DFS). Results: A total of 441 patients were analyzed. Of these, 176 patients (39.9%) underwent PM. Median OS was 46.4 months (95%CI: 34.1-58.7) for the PM group and 56.5 months (95%CI: 37.1-75.9) for the no-PM group (P = 0.188), with a median DFS of 26.7 months (95%CI: 15.7-37.7) and 24.9 months (95%CI: 18.1-31.7), respectively (P = 0.883). Conclusions: These results suggest that PM does not increase the risk of tumor recurrence or decrease long-term survival.
29-ott-2017
117
2
198
206
Does the Pringle maneuver affect survival and recurrence following surgical resection for hepatocellular carcinoma? A western series of 441 patients / Famularo, S; Giani, A; Di Sandro, S; Sandini, M; Giacomoni, A; Pinotti, E; Lauterio, A; Gianotti, L; De Carlis, L; Romano, F. - In: JOURNAL OF SURGICAL ONCOLOGY. - ISSN 0022-4790. - 117:2(2018), pp. 198-206. [10.1002/jso.24819]
Famularo, S; Giani, A; Di Sandro, S; Sandini, M; Giacomoni, A; Pinotti, E; Lauterio, A; Gianotti, L; De Carlis, L; Romano, F
File in questo prodotto:
File Dimensione Formato  
57.pdf

non disponibili

Tipologia: Post-print dell'autore (bozza post referaggio)
Dimensione 559.02 kB
Formato Adobe PDF
559.02 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1200928
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 17
social impact