The one-pot stepwise reductive amination of arylaldehydes with nitroarenes is described, using reusable nickel nanoparticles (Ni-pol) as catalyst and NaBH4 as mild, inexpensive, and safe reducing agent. The proposed catalytic system holds several advantages such as the use of a non-precious and earth-abundant metal, the facile separation of the catalyst from the reaction mixture by centrifugation, excellent stability towards air and moisture, very mild reaction conditions, good recyclability, broad substrate scope with good to excellent yields, and easy scalability (up to 1.0 g). FESEM analyses indicate that the active species are cubic nanocrystals of Ni in the average cross section value of 35 nm with a quite narrow (25–45 nm) and monomodal distribution, which becomes bimodal with the recycling reactions but without agglomeration.

Mild and efficient synthesis of secondary aromatic amines by one-pot stepwise reductive amination of arylaldehydes with nitroarenes promoted by reusable nickel nanoparticles / Fiore, A. M.; Romanazzi, G.; Dell'Anna, M. M.; Latronico, M.; Leonelli, C.; Mali, M.; Rizzuti, A.; Mastrorilli, P.. - In: MOLECULAR CATALYSIS. - ISSN 2468-8231. - 476:(2019), pp. 1-9. [10.1016/j.mcat.2019.110507]

Mild and efficient synthesis of secondary aromatic amines by one-pot stepwise reductive amination of arylaldehydes with nitroarenes promoted by reusable nickel nanoparticles

Leonelli C.
Writing – Review & Editing
;
Rizzuti A.
Writing – Original Draft Preparation
;
2019

Abstract

The one-pot stepwise reductive amination of arylaldehydes with nitroarenes is described, using reusable nickel nanoparticles (Ni-pol) as catalyst and NaBH4 as mild, inexpensive, and safe reducing agent. The proposed catalytic system holds several advantages such as the use of a non-precious and earth-abundant metal, the facile separation of the catalyst from the reaction mixture by centrifugation, excellent stability towards air and moisture, very mild reaction conditions, good recyclability, broad substrate scope with good to excellent yields, and easy scalability (up to 1.0 g). FESEM analyses indicate that the active species are cubic nanocrystals of Ni in the average cross section value of 35 nm with a quite narrow (25–45 nm) and monomodal distribution, which becomes bimodal with the recycling reactions but without agglomeration.
2019
476
1
9
Mild and efficient synthesis of secondary aromatic amines by one-pot stepwise reductive amination of arylaldehydes with nitroarenes promoted by reusable nickel nanoparticles / Fiore, A. M.; Romanazzi, G.; Dell'Anna, M. M.; Latronico, M.; Leonelli, C.; Mali, M.; Rizzuti, A.; Mastrorilli, P.. - In: MOLECULAR CATALYSIS. - ISSN 2468-8231. - 476:(2019), pp. 1-9. [10.1016/j.mcat.2019.110507]
Fiore, A. M.; Romanazzi, G.; Dell'Anna, M. M.; Latronico, M.; Leonelli, C.; Mali, M.; Rizzuti, A.; Mastrorilli, P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1200507
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