DENTAL ROOT SURFACE TREATMENT WITH ETHYLENEDIAMINETETRAACETIC ACID DOES NOT IMPROVE ENAMEL MATRIX DERIVATIVE PEPTIDE TREATMENT WITHIN INTRABONY DEFECTS: A RETROSPECTIVE STUDY

Introduction The dental root surface treatment is quite often considered a key factor in achieving regeneration of the periodontal defect. The aim of this retrospective study was to compare the 12-month clinical outcomes obtained by the application of enamel matrix derivative peptide (EMP) with and without EDTA dental root conditioning in intrabony 2-3-wall defect treated by minimally invasive surgical therapy (MIST). Material and Methods Twenty-two healthy patients, affected from moderate or severe chronic periodontitis, with a 2-3-wall intrabony defect (≥4 mm deep and ≥2 mm wide), were selected. Each patient was treated by MIST Technique and EMP was applied into the defect during the surgery, on the dental roots. However, in the treatment group-1 (TG1) the root surfaces were not previously conditioned whilst in the treatment group-2 (TG2) root surfaces were conditioned by EDTA. Immediately before surgery (T0) and 12-month after (T2) the probing depth (PD) and gingival recession (GR) were registered at the experimental sites and the full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) were also registered. Results No statistically significant differences were shown between TG1 and TG2 at T0 and T1 in term of PD, GR, FMPS while a statistically significant greater FMBS was recorded in TG2 at T1. PD, FMPS and FMBS indices significantly decreased between T0 and T1 both in TG1 and TG2 (p<0.05). GR increase resulted not statistically significant both in TG1 and TG2 (p<0.05) between T0 and T1. Conclusions In this retrospective study both the treatments achieved favourable and comparable clinical results. The PD and GR were similar between the two treatment groups (TG1 and TG2) in the single phases considered (T0 and T1) and during the follow-up (T0-T1). The EDTA conditioning of dental root surfaces did not seem efficient to improve the clinical results in the treatment of 2-3-wall periodontal defects.