BK virus (BKV) is an opportunistic pathogen in those with impaired immunity. Viral replication is generally asymptomatic but is able to induce cytopathic alterations in renal cells. If BKV infection is left untreated, it leads to BKV-associated nephropathy (BKVAN) and graft loss. There is scarce experience in the management of BKV infection in kidney transplant recipients living with HIV. We report the successful treatment of BKVAN in an HIV-positive kidney transplant recipient who experienced BKV replication in the immediate post-transplantation period. A change in therapy from calcineurin inhibitor to sirolimus, steroid withdrawal and a short course of an immunomodulatory agent (leflunomide) controlled BKV viremia in the absence of drug side-effects or impairment of graft function.

Successful treatment of BK virus associated-nephropathy in a human immunodeficiency virus-positive kidney transplant recipient / Alfano, Gaetano; Fontana, Francesco; Guaraldi, Giovanni; Cappelli, Gianni; Mussini, Cristina. - In: INTERNATIONAL JOURNAL OF STD & AIDS. - ISSN 0956-4624. - 31:4(2020), pp. 387-391-391. [10.1177/0956462419900853]

Successful treatment of BK virus associated-nephropathy in a human immunodeficiency virus-positive kidney transplant recipient

Alfano, Gaetano;Fontana, Francesco;Guaraldi, Giovanni;Cappelli, Gianni;Mussini, Cristina
2020

Abstract

BK virus (BKV) is an opportunistic pathogen in those with impaired immunity. Viral replication is generally asymptomatic but is able to induce cytopathic alterations in renal cells. If BKV infection is left untreated, it leads to BKV-associated nephropathy (BKVAN) and graft loss. There is scarce experience in the management of BKV infection in kidney transplant recipients living with HIV. We report the successful treatment of BKVAN in an HIV-positive kidney transplant recipient who experienced BKV replication in the immediate post-transplantation period. A change in therapy from calcineurin inhibitor to sirolimus, steroid withdrawal and a short course of an immunomodulatory agent (leflunomide) controlled BKV viremia in the absence of drug side-effects or impairment of graft function.
2020
19-feb-2020
31
4
387-391
391
Successful treatment of BK virus associated-nephropathy in a human immunodeficiency virus-positive kidney transplant recipient / Alfano, Gaetano; Fontana, Francesco; Guaraldi, Giovanni; Cappelli, Gianni; Mussini, Cristina. - In: INTERNATIONAL JOURNAL OF STD & AIDS. - ISSN 0956-4624. - 31:4(2020), pp. 387-391-391. [10.1177/0956462419900853]
Alfano, Gaetano; Fontana, Francesco; Guaraldi, Giovanni; Cappelli, Gianni; Mussini, Cristina
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1198364
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